Search for dissertations about: "abc dissertations"
Showing result 1 - 5 of 24 swedish dissertations containing the words abc dissertations.
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1. Intestinal barriers to oral drug absorption: Cytochrome P450 3A and ABC-transport proteins
Abstract : The subject of this thesis was to study two intestinal barriers to oral drug bioavailability, drug efflux proteins of the ABC-transporter family, and in particular ABCB1/P-glycoprotein (Pgp), and the drug metabolizing enzyme cytochrome P450 (CYP) 3A4. At the onset of this thesis, similarities between CYP3A4 and Pgp in terms of their tissue distribution and gene regulation, along with overlapping substrate specificities, had generated the hypothesis that CYP3A4 and Pgp may have a complementary function and thus form a coordinated intestinal barrier to drug absorption and gut wall metabolism. READ MORE
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2. The ABC of KRAB zinc finger proteins
Abstract : All living organisms consist of cells and the identity of a cell is defined by the genes it expresses. To assure proper function, a cell receives continuous information on which genes to turn on and off. This information is, to a large extent, provided by transcription factors. READ MORE
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3. Double Pion Production in the dd to αππ reaction
Abstract : The reaction dd → 4Heππ has been measured exclusively for the first time. The measurements were performed at Td = 712 MeV and Td = 1029 MeV, with the WASA detector assembly at CELSIUS (Uppsala-Sweden). The aim was to investigate a long standing puzzle, the so called ABC effect. READ MORE
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4. ATP-Binding Cassette Efflux Transporters and Passive Membrane Permeability in Drug Absorption and Disposition
Abstract : Transport into and across the cells of the human body is a prerequisite for the pharmacological action of drugs. Passive membrane permeability and active transport mechanisms are major determinants of the intestinal absorption of drugs, as well as of the distribution to target tissues and the subsequent metabolism and excretion from the body. READ MORE
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5. In vivo Pharmacokinetics of Two New Thrombin Inhibitor Prodrugs : Emphasis on Intestinal and Hepatobiliary Disposition and the Influence of Interacting Drugs
Abstract : Biliary excretion is an important elimination route for many drugs and metabolites. For such compounds, it is important to know the extent of excretion and drug exposure in the bile, e.g., for the risk assessment of drug interactions, liver toxicity and the effects of genetic variants. READ MORE
