Search for dissertations about: "abdominal adiposity"

Showing result 11 - 15 of 16 swedish dissertations containing the words abdominal adiposity.

  2. 11. Interplay between hormones, nutrients and adipose depots in the regulation of insulin sensitivity : an experimental study in rat and human adipocytes

    Author : Magdalena Lundgren; Jan Eriksson; Jonas Burén; Eva Degerman; Umeå universitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; adipose tissue; cAMP; glucocorticoids; glucose; insulin; insulin resistance; lipolysis; subcutaneous fat; type 2 diabetes; visceral fat; Medicine; Medicin;

    Abstract : Obesity and specifically central obesity is related to insulin resistance, type 2 diabetes and other components of the so-called metabolic syndrome. The aim of this study was to elucidate the interplay between hormones, nutrients and adipose depots in normal and insulin-resistant fat cell metabolism. READ MORE

  4. 12. On the importance of fat cell size, location and signaling in insulin resistance

    Author : Niclas Franck; Fredrik Nyström; Torbjörn Lindström; Anna Krook; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Obesity has reached epidemic proportions worldwide and is associated with insulin resistance, type 2 diabetes and cardiovascular disease. During the past decades, substantial evidence has demonstrated that not only the amount of adipose tissue constitutes a major determinant in the development of metabolic disorders, but also the distribution. READ MORE

  5. 13. Molecular mechanisms of estrogen action in relation to metabolic disease

    Author : Lovisa Lundholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Estrogens have multiple effects on the body. Most studied are the effects on female reproduction. In this thesis, we have focused on the metabolic effects of estrogens. Estrogen treatment decreases adipose tissue mass and has anti-diabetic effects in humans and mice. READ MORE

  6. 14. Genetic predisposition and dietary factors in relation to adiponectin and insulin resistance

    Author : He Gao; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Diabetes mellitus is a global health problem, owing to the high prevalence and enormous associated economic burden. Insulin resistance is a critical condition to the development of type 2 diabetes (T2D). Adiponectin, a hormone secreted by the adipose cells, has attracted much attention for its insulin-sensitizing and anti-diabetic effects. READ MORE

  7. 15. Alterations in peripheral glucocorticoid metabolism : effects of weight changes

    Author : Kotryna Simonyté; Cecilia Mattsson; Bo Angelin; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 11ß Hydroxysteroid dehydrogenase 1; obesity; glucocorticoids; cortisol; phosphoenolpyruvate carboxykinase; adipose tissue; liver; Endocrinology; Endokrinologi; medicin; Medicine;

    Abstract : Background: An important role has been suggested for tissue-specific glucocorticoid metabolism in the development of obesity and its complications. 11ß hydroxysteroid dehydrogenase 1 (11ßHSD1) is an enzyme that catalyzes the interconversion of biologically inactive cortisone to active cortisol, thereby regulating its access to glucocorticoid receptors in target tissues. READ MORE