Search for dissertations about: "accumbens"

Showing result 1 - 5 of 67 swedish dissertations containing the word accumbens.

  2. 1. Nicotine sensitization and the effects of extended withdrawal - behavioral, neurochemical and electrophysiological studies in the rat

    Author : Julia Morud; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Abstinence; Dopamine; Elevated plus-maze; GABA; Inhibitory control; Nicotine; Nucleus accumbens; Sensitization;

    Abstract : Tobacco use is one of the primary factors for global burden of disease and often results in life-long nicotine addiction, only a small percentage users are able to maintain cessation. The life-long addiction together with a high relapse risk might be connected to drug-induced altered neural circuits. READ MORE

  4. 2. Taurine and dopamine-related effects of ethanol. An experimental study in rodents

    Author : Lisa Ulenius; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Addiction; Alcohol; Caffeine; Nucleus accumbens; Microdialysis;

    Abstract : The reinforcing properties of alcohol (ethanol) are associated with activation of the mesolimbic dopamine system and the concomitant increase in dopamine in the nucleus accumbens (nAc). Changes in this system are thought to be a predominant underlying factor in promoting excessive alcohol intake and alcohol use disorder. READ MORE

  5. 3. Glycine receptors in the central nervous system - development, distribution and relation to actions of alcohol

    Author : Susanne Jonsson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glycine receptor; nucleus accumbens; alcohol; gene expression; dopamine;

    Abstract : The widespread consumption of alcohol and the great socioeconomic impact of alcohol abuse and addiction have contributed to the extensive investigations of this substance. Despite great efforts there is still uncertainty concerning how alcohol exerts its effects and the mechanisms behind the transition from consumption to addiction. READ MORE

  6. 4. Preclinical investigations of GlyT-1 inhibition as a new concept for treatment of alcohol dependence

    Author : Helga Lidö Höifödt; Göteborgs universitet; []
    Keywords : Psykiatri experimentell ; Neurofarmakologi; alcohol; dependence; dopamine; GlyT-1 inhibition; nucleus accumbens; reward;

    Abstract : Alcohol addiction and abuse is a main contributor to the global burden of disease and is a high public health priority. Alcohol addiction is a chronically relapsing neurobiological disorder affecting multiple neurotransmitter systems. READ MORE

  7. 5. Conditional and non-conditional reward-related responses to alcohol. Nicotinic mechanisms

    Author : Elin Löf; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ethanol; nicotine; ventral tegmental area; nucleus accumbens; dopamine; nicotinic acetylcholine receptor; gamma-amino-butyric acid receptor A; conditioned reinforcement; in vivo microdialysis; rat;

    Abstract : The mesolimbic dopamine system is believed to mediate the positive reinforcing and rewarding effects of addictive drugs by increasing dopamine levels in its terminal area, the nucleus accumbens (nAc). Nicotinic acetylcholine receptors (nAChRs) within this system appear important for the pharmacological actions of both alcohol and nicotine, which may explain the frequent co-abuse of these two drugs. READ MORE