Search for dissertations about: "acetylcholinesterase inhibition"

Showing result 1 - 5 of 8 swedish dissertations containing the words acetylcholinesterase inhibition.

  2. 1. Selective inhibition of acetylcholinesterase 1 from disease-transmitting mosquitoes : design and development of new insecticides for vector control

    Author : Cecilia Engdahl; Anna Linusson; Fredrik Ekström; Zoran Radić; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; acetylcholinesterase; non-covalent inhibitor; vector control; insecticide; mosquito; vector-borne disease; high throughput screening; rational design; biokemi; Biochemistry; datorlingvistik; computational linguistics;

    Abstract : Acetylcholinesterase (AChE) is an essential enzyme with an evolutionary conserved function: to terminate nerve signaling by rapid hydrolysis of the neurotransmitter acetylcholine. AChE is an important target for insecticides. READ MORE

  4. 2. Dynamic Systems for Screening, Control and Identification of Protein-Ligand Interactions

    Author : Rikard Larsson; Olof Ramström; Michel R. Gagné; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Dynamic combinatorial chemistry; Dynamic kinetic combinatorial resolution; Catalytic screening; Transthiolesterification; Thiol disulfide interchange; Nitroaldol reaction; Lectins; Hydrolases; Dynamic self-inhibition; Organic chemistry; Organisk kemi;

    Abstract : Dynamic systems for screening, control and identification of different protein-ligand interactions are presented. Dynamic chemistry is used to produce new compounds/constituents in situ that can interact with a target molecule. Several entities can be introduced at the same time and interact with one another. READ MORE

  5. 3. Molecular changes of acetylcholinesterase and butyrylcholinesterase in Alzheimer patients during the natural couse of the disease and treatment with cholinesterase inhibitors : insight into neurochemical mechanisms affecting the progression of the disease

    Author : Taher Darreh-Shori; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimer disease; acetylcholinesterase; butyrylcholinesterase; cholinesterase inhibitors;

    Abstract : Deficits in central cholinergic neurotransmission in the brain correlate with cognitive impairment in Alzheimer disease (AD) patients. This fact has resulted in the introduction of cholinesterase inhibitors (ChEls) e.g. READ MORE

  6. 4. Functional brain activity in Alzheimer patients as studied by multi-tracer positron emission tomography : effects of treatment with cholinesterase inhibitors

    Author : Ahmadul Kadir; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimer’s disease; cholinesterase inhibitors; positron emission tomography; nicotinic acetylcholine receptor; acetylcholinesterase; multi-tracer; 11C-nicotine; 11C-PMP; 18F-FDG; 11C-PIB; donepezil; rivastigmine; galantamine; phenserine.;

    Abstract : Alzheimer’s disease (AD) is a progressive neurodegenerative disease accompanied by cognitive impairment and disturbances in several neurotransmitter systems, especially the cholinergic system. Studies have correlated the cognitive impairment observed in AD patients with a deficit in central cholinergic neurotransmission. READ MORE

  7. 5. Advanced Mass Spectrometry Imaging in Neuropharmacology

    Author : Theodosia Vallianatou; Per E. Andrén; Anna Nilsson; Mohammadreza Shariatgorji; Maria Karlgren; Irena Loryan; Nathalie Agar; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mass spectrometry imaging; neuropharmacology; blood brain barrier; drug-drug interactions; aging; tacrine;

    Abstract : Mass spectrometry imaging (MSI) has emerged as a valuable approach for mapping multiple molecular species in sections of diverse tissues. It enables simultaneous detection of numerous compounds (from neurotransmitters to small proteins) in the brain at relatively high lateral resolution (>5 μm) on a routine basis. READ MORE