Search for dissertations about: "achiral"

Showing result 1 - 5 of 25 swedish dissertations containing the word achiral.

  2. 1. On the Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors : From Tripeptides to Achiral Compounds

    Author : Pernilla Örtqvist; Anja Sandström; Mats Larhed; Anders Hallberg; Morten Grøtli; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hepatitis C virus; NS3 protease inhibitor; structure-activity relationship; resistance; 2 1H -pyrazinone; phenylglycine; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; Läkemedelskemi;

    Abstract : Infection by the hepatitis C virus (HCV) leads to inflammation of the liver, i.e. hepatitis. The acute infection often progresses to a chronic phase during which the liver function is gradually impaired. READ MORE

  4. 2. Packed Column Supercritical Fluid Chromatography : Applications in Environmental Chemistry

    Author : Nicole Riddell; Bert van Bavel; Robert McCrindle; Ingrid Ericson Jogsten; Jake Ryan; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Supercritical Fluid Chromatography; Mass Spectrometry; Ionization; POPs; APPI; APCI; chiral; achiral; packed column;

    Abstract : Although gas and liquid chromatography have emerged as dominant separation techniques in environmental analytical chemistry, these methods do not allow for the concurrent analysis of chemically diverse groups of persistent organic pollutants (POPs). There are also a small number of compounds which are not easily amenable to either of these traditional separation techniques. READ MORE

  5. 3. From achiral to chiral analysis of citalopram

    Author : Björn Carlsson; Yngve Bergqvist; Linköpings universitet; []
    Keywords : depression; noradrenaline; dopamine; serotonin; citalopram; selective serotonin-reuptake inhibitor SSRI ; high-performance liquid chromatography HPLC ; therapeutic drug monitoring TDM ; enantioselective separation; MEDICINE; MEDICIN;

    Abstract : Within the field of depression the “monoamine hypothesis” has been the leading theory to explain the biological basis of depression. This theory proposes that the biological basis of depression is due to a deficiency in one or more of three key neurotransmitter systems, namely noradrenaline, dopamine and serotonin which are thought to mediate the therapeutic actions of virtually every known antidepressant agent. READ MORE

  6. 4. Tuning lipase-catalysed resolution of chiral alcohols and acids & synthesis of achiral and chiral 1,2,4-trioxane antimalarials

    Author : Sunil Sabbani; Mittuniversitetet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi;

    Abstract : .... READ MORE

  7. 5. Development of LC-MS/MS Methods for the Analysis of Chiral and Achiral Pharmaceuticals and Metabolites in Aqueous Environmental Matrices

    Author : Victoria K.H. Barclay; Curt Pettersson; Monika Johansson; Niklas Tyrefors; Mohamed Abdel-Rehim; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environmental water matrices; chiral separation; LC-MS MS; trace analysis; method development; active pharmaceutical ingredients; metabolites; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Abstract : This thesis describes the development of liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for the trace analysis of active pharmaceutical ingredients (APIs) and their metabolites in aqueous environmental matrices. The research was focused on the development of chiral LC-MS/MS methods for the analysis of fluoxetine and metoprolol, as well as their chiral metabolites in environmental water samples. READ MORE