Search for dissertations about: "activation barrier"

Showing result 1 - 5 of 165 swedish dissertations containing the words activation barrier.

2. 1. Voltage sensor activation and modulation in ion channels

   Author : Christine S Schwaiger; Lindahl Erik; Paolo Carloni; KTH; []
   Keywords : NATURAL SCIENCES; NATURVETENSKAP; activation; deactivation; inactivation; voltage sensor; VSD; gating; Kv1.2-2.1; Shaker; F233; hydrophobic barrier;

   Abstract : Voltage-gated ion channels play fundamental roles in neural excitability, they are for instance responsible for every single heart beat in our bodies, and dysfunctional channels cause disease that can be even lethal. Understanding how the voltage sensor of these channels function is critical for drug design of compounds targeting neuronal excitability. READ MORE

4. 2. Dynamics of the voltage-sensor domain in voltage-gated ion channels : Studies on helical content and hydrophobic barriers within voltage-sensor domains

   Author : Christine S. Schwaiger; Erik Lindahl; Lynn Kamerlin; KTH; []
   Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; activation; deactivation; inactivation; voltage-sensor; VSD; Kv1.2- 2.1; F233; hydrophobic barrier; alpha-helix; 3 10 -helix; Biological physics; Biologisk fysik;

   Abstract : Voltage-gated ion channels play fundamental roles in neural excitability and thus dysfunctional channels can cause disease. Understanding how the voltage-sensor of these channels activate and inactivate could potentially be useful in future drug design of compounds targeting neuronal excitability. READ MORE

5. 3. Perturbation of the epithelial barrier by enteric pathogens

   Author : Farideh Tafazoli; Magnusson Karl-Eric; Hakon Leffler; Linköpings universitet; []
   Keywords : enteric pathogens: signal transduction; barrier function; MEDICINE; MEDICIN;

   Abstract : Gastrointestinal infections in humans have been associated with a number of diseased condition, including stomach ulcers, gastroenteritis, Crohn's disease, and rheumatic arthritis. Such infections often cause altered intestinal permeability through perturbation of the tight junctions that hold epithelial cells together. READ MORE

6. 4. Protein Folding Studied by Site Directed Mutagenesis

   Author : Tomas Ternström; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Metabolism; Biokemi; metabolism; Biochemistry; Transition state; Activation Barrier; Two-State; Protein Folding; Protein Engineering;

   Abstract : The N-terminal RNA binding domain of U1A has been shown to fold in a two-state process without accumulating any intermediates. U1A has a symmetrically curved chevron plot which seems to result mainly from changes of the transition state. READ MORE

7. 5. Endothelial Barrier Dysfunction in Multiple Organ Injury. An Experimental Study in Rats

   Author : Xiaoming Deng; Lund Kirurgi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; orthopaedics; Surgery; Endothelial barrier permeability; Multiple organ dysfunction syndrome; Zymosan; traumatology; Kirurgi; ortopedi; traumatologi;

   Abstract : Multiple organ dysfunction syndrome (MODS) is still the leading cause of mortality in the surgical intensive care unit. The effect on among others endothelial barrier permeability, reticuloendothelial function, organ function and protease-antiprotease activities was studied following a variety of challenges, especially over-activation of macrophages induced by intraperitoneal administration of zymosan. READ MORE