Search for dissertations about: "active-sites"

Showing result 1 - 5 of 93 swedish dissertations containing the word active-sites.

  1. 1. Chiral recognition on cellulases : The active sites of the enzymes are involved

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Hongbin Henriksson; Uppsala universitet.; [2000]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; NATURAL SCIENCES Chemistry Biochemistry; NATURVETENSKAP Kemi Biokemi; biokemi; Biochemistry;

    Abstract : Two cellobiohydrolases (CBH I and CBH II) and endoglucanase I (EG I) fromTrichoderma reesei, and CBH 58 from Phanerochaete chrysosporium were immobilized onsilica as chiral stationary phases (CSPs) in HPLC for enantioseparation of a group ofpharmaceutical compounds. CBH I and CBH 58 wore excellent chiral selectors for β-adrenergic blocking agents, whereas CBH II displayed good enantioselectivity for someother compounds The CBHs share the common feature that their active sites are located intunnels. READ MORE

  2. 2. Dinuclear metal complexes modelling active sites of metallohydrolases

    University dissertation from Uppsala : Acta Universitatis Upsaliensis

    Author : Martin Jarenmark; Lunds universitet.; Lund University.; [2009]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Bioinorganic chemistry; enzymes; hydrolases; models; dinuclear; heterodinuclear; phosphotriesterase; purple acid phophatase;

    Abstract : To study the active sites of dinuclear metallohydrolases new metal complexes that model these sites both in structure and function have been synthesized using two new phenol based dinucleating ligands, 2-(N-isopropyl-N-((2-pyridyl)methyl)aminomethyl)-6-(N-(carboxylmethyl)-N-((2-pyridyl)methyl)aminomethyl)-4-methylphenol (IPCPMP) and 2,6-Bis[N-(N-(carboxymethyl)-N-(pyridylmethyl)amine)methyl]-4-methylphenolate (BCPMP). Both ligands contain pyridyl, tertiary amine and carboxylate groups but in IPCPMP one carboxylate donor is exchanged for a non-coordinating group yielding an unsymmetric ligand while BCPMP is symmetric with identical sets of ligands on either side of the phenol group. READ MORE

  3. 3. Theoretical studies of mononuclear non-heme iron active sites

    University dissertation from Stockholm : Fysikum

    Author : Arianna Bassan; Stockholms universitet.; [2004]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; quantum chemistry; enzyme catalysis; iron enzymes; NATURAL SCIENCES Chemistry Theoretical chemistry Quantum chemistry; NATURVETENSKAP Kemi Teoretisk kemi Kvantkemi;

    Abstract : The quantum chemical investigations presented in this thesis use hybrid density functional theory to shed light on the catalytic mechanisms of mononuclear non-heme iron oxygenases, accommodating a ferrous ion in their active sites. More specifically, the dioxygen activation process and the subsequent oxidative reactions in the following enzymes were studied: tetrahydrobiopterin-dependent hydroxylases, naphthalene 1,2-dioxygenase and α-ketoglutarate-dependent enzymes. READ MORE

  4. 4. On the Character of Active Sites in Copper Exchanged Zeolites during NH3-SCR

    University dissertation from ; Chalmers tekniska högskola; Gothenburg

    Author : Lin Chen; [2017]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cu-SSZ-13; SSIE; O2-dissociation; Al-distribution; NH3-SCR; Chabazite; O2-activation;

    Abstract : Nitrogen oxides (NOx) are formed during combustion in diesel engines and one current approach to reduce NOx to N2 is selective catalytic reduction with NH3 as reducing agent (NH3-SCR). To acquire both high activity and selectivity, the active site is often atomically dispersed metal atom, so-called single-site catalysts. READ MORE

  5. 5. Leukotriene A4 hydrolase : Exploration of the active sites and catalytic mechanisms by site-directed mutagenesis

    University dissertation from Stockholm : Karolinska Institutet, false

    Author : Martina Blomster Andberg; Karolinska Institutet.; Karolinska Institutet.; [1997]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Leukotriene (LT) A4 is a pivotal intermediate in the biosynthesis of leukotrienes, a family of potent lipid mediators involved in a variety of inflammatory and allergic disorders. The bifunctional zinc metalloenzyme LTA4 hydrolase converts LTA4 into LTB4, one of the most potent chemotaxins known to date. READ MORE