Search for dissertations about: "acute leukemias treatment"
Showing result 1 - 5 of 11 swedish dissertations containing the words acute leukemias treatment.
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1. Population-based studies on acute leukemias - lessons from the Swedish Adult Acute Leukemia Registry
Abstract : Acute leukemia (AL) is a rare, potentially curable, aggressive neoplasm of hematopoietic origin. AL is a heterogeneous disease and is further subdivided according to clinical and biological features. READ MORE
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2. Molecular Genetic Studies of Ph-positive Leukemias and the BCR and ABL Genes
Abstract : In the present thesis molecular genetic methods were used to address different biological and clinical aspects of Philadelphia (Ph) chromosome-positive leukemias and the BCR and ABL genes. In the first study, children with Ph-positive chronic myeloid leukemia (CML) were found to have essentially the same breakpoint locations in BCR as adults, a pattern which differs from the one seen in Ph-positive acute lymphoid leukemia (ALL). READ MORE
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3. Ultrasensitive Molecular Monitoring of Breast Cancer and Acute Myeloid Leukemia
Abstract : Cancer is the common name to a group of biologically diverse malignant neoplastic diseases. Approximately 18 million people are diagnosed with cancer annually and 8.8 million patients die from it. Tumorigenesis and progression of cancer are driven by alterations in the cancer cell genome. READ MORE
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4. DNA methylation signatures in precursor lymphoid neoplasms : with focus on clinical implications & the biology behind
Abstract : Precursor lymphoid neoplasms, namely acute lymphoblastic leukemias (ALL) and lymphoblastic lymphomas (LBL), are characterized by an aggressive proliferation of malignant progenitor B- or T-cells. To improve risk classification at diagnosis, better prognostic and treatment stratifying biomarkers are needed. READ MORE
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5. Mechanisms of leukemia-induced immunosuppression
Abstract : This thesis aimed to define the role of reactive oxygen species (ROS), produced by the NADPH oxidase of myeloid cells, in the regulation of lymphocyte function with focus on ROS-induced dysfunction of natural killer (NK) cells and T lymphocytes in myeloid leukemia. In Paper I, a novel mechanism is presented by which specifically activated T lymphocytes evade inactivation by ROS after antigen presentation. READ MORE