Search for dissertations about: "acute myeloid leukemia"

Showing result 16 - 20 of 149 swedish dissertations containing the words acute myeloid leukemia.

  2. 16. Aberrant DNA methylation in acute myeloid leukemia

    Author : Ying Qu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : DNA methylation is an important epigenetic mechanism that influences development and cancer by regulating gene transcription. Aberrant DNA methylation is a feature of cancer including acute myeloid leukemia (AML). READ MORE

  4. 17. Mechanisms of leukemia-induced immunosuppression

    Author : Johan Aurelius; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; Immunosuppression; Immunotherapy; Reactive oxygen species; PARP-1; NK cells; T cells;

    Abstract : This thesis aimed to define the role of reactive oxygen species (ROS), produced by the NADPH oxidase of myeloid cells, in the regulation of lymphocyte function with focus on ROS-induced dysfunction of natural killer (NK) cells and T lymphocytes in myeloid leukemia. In Paper I, a novel mechanism is presented by which specifically activated T lymphocytes evade inactivation by ROS after antigen presentation. READ MORE

  5. 18. CRISPR Screens Identify Candidate Therapeutic Targets in Leukemia

    Author : Maria Rodriguez Zabala; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; CRISPR screen; leukemia stem cell; cell surface receptor; metabolism; immunotherapy; CXCR4; GLUT1; TFR1; H2-K1;

    Abstract : Acute myeloid leukemia (AML) is a complex hematological malignancy marked by proliferation of immature myeloid cells with a dismal 5-year survival. A major challenge is the persistence of leukemia stem cells (LSCs) after standard treatment, leading to relapse. READ MORE

  6. 19. Redox reactions in cancer: impact and regulation

    Author : Hanna Grauers Wiktorin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Immunotherapy; reactive oxygen species; NOX2; histamine dihydrochloride; myeloid-derived suppressor cells; checkpoint inhibition; acute myeloid leukemia; chronic myeloid leukemia;

    Abstract : The reduction-oxidation (redox) reaction involves a change in the oxidation state of molecules where a molecule that donates an electron is oxidized and a molecule that accepts an electron is reduced. The NADPH oxidase of myeloid cells, NOX2, is a major source of oxidants in the form of reactive oxygen species (ROS), which are short-lived oxygen derivatives. READ MORE

  7. 20. On the role of Natural Killer cell immunogenetics for the outcome of immunotherapy in acute myeloid leukemia

    Author : Brwa Ali Hussein; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Natural killer cells; Acute Myeloid Leukemia; immunotherapy; HDC IL-2; NKG2A; NK education; SNPs; NK activating receptors; HLA class I;

    Abstract : Numerous studies have revealed that natural killer cells have fundamental roles as effector cells in myeloid leukemias. Thus, understanding NK cell-related biomarkers that influence clinical outcome are warranted. READ MORE