Search for dissertations about: "acute myeloid leukemia"

Showing result 6 - 10 of 149 swedish dissertations containing the words acute myeloid leukemia.

  2. 6. Epidemiological studies in de novo and secondary acute leukemia

    Author : Erik Hulegårdh; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute leukemia; ALL; AML; adult; Secondary acute leukemia; MDS; MPN;

    Abstract : Abstract Background Acute leukemia (AL) is a rare blood cancer with poor prognosis in adult patients. Socioeconomic factors are known to impact cancer outcomes, but have not been adequately examined among adult AL patients. READ MORE

  4. 7. Functional Screens Identify Vulnerabilities in Acute Leukemia

    Author : Ramprasad Ramakrishnan; Avdelningen för klinisk genetik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute leukemia; CRISPR; CXCR4; CXCL12; TNFSF13; DUX4; Interleukin 4; leukemia stem cell; macrophage;

    Abstract : Acute leukemia refers to a group of aggressive hematological malignancies of myeloid and lymphoid lineages termed acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) respectively. Acute leukemia is characterized by the presence of underlying genetic aberrations which alter the biology of normal hematopoietic cells resulting in the accumulation of immature abnormally differentiated blast cells. READ MORE

  5. 8. Multi-omics analysis of relapsed acute myeloid leukemia

    Author : Svea Stratmann; Linda Holmfeldt; Caroline Heckman; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia AML ; relapse and resistance; next generation sequencing WGS WES ; RNA-sequencing; DNA methylation; HiRIEF LC-MS; proteogenomics; Molekylär medicin; Molecular Medicine;

    Abstract : The prognosis for patients suffering from acute myeloid leukemia (AML) remains unsatisfactory and survival is often measured in months. Although the majority of patients achieve complete remission after aggressive treatment, most of them relapse within a few years. READ MORE

  6. 9. Studies of New Signal Transduction Modulators in Acute Myeloid Leukemia

    Author : Anna Eriksson; Martin Höglund; Rolf Larsson; Bjørn Tore Gjertsen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; Targeted therapies; Drug development; Tyrosine kinase inhibition; AKN-032; AKN-028; Internmedicin; Internal Medicine;

    Abstract : Acute myeloid leukemia (AML) is a life-threatening malignant disorder with dismal prognosis. AML is characterized by frequent genetic changes involving tyrosine kinases, normally acting as important mediators in many basic cellular processes. READ MORE

  7. 10. Prognostic markers in acute myeloid leukemia : A candidate gene approach

    Author : Ingrid Jakobsen; Kourosh Lotfi; Henrik Gréen; Anna Fyrberg; Christian Thiede; Linköpings universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : The standard treatment of acute myeloid leukemia (AML) consists of induction chemotherapy, most commonly daunorubicin together with the nucleoside analogue cytarabine (Ara-C), followed by consolidation chemotherapy and in selected cases allogenic stem cell transplantation (allo-SCT). Despite a high initial response rate, a considerable proportion of all AML cases eventually suffer from relapse and the five-year overall survival rate in patients >60 years is only around 15%. READ MORE