Search for dissertations about: "acylated cyanohydrins"

Found 5 swedish dissertations containing the words acylated cyanohydrins.

2. 1. Efficient Synthesis and Analysis of Chiral Cyanohydrins

   Author : Stina Lundgren; Christina Moberg; Ben Feringa; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; asymmetric catalysis; cyanohydrins; microreactor; polymersupported catalyst; ketonitriles; titanium; lanthanide; Lewis acid; Lewis base; Organic chemistry; Organisk kemi;

   Abstract : This thesis deals with the development of new methods for efficient synthesis and analysis in asymmetric catalysis. It focuses on the preparation of chiral cyanohydrins by enantioselective addition of cyanide to prochiral aldehydes. READ MORE

4. 2. New Methods for Chiral Cyanohydrin Synthesis

   Author : Erica Wingstrand; Christina Moberg; Benjamin List; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; acyl cyanides; asymmetric synthesis; biocatalysis; cyanide; cyanohydrins; dual activation; enzymes; high-throughput screening; Lewis acid; Lewis base; metal catalysis; minor enantiomer recycling; salen; titanium; Chemistry; Kemi;

   Abstract : This thesis deals with method development in asymmetric catalysis and specifically syntheses of enantioenriched O-functionalized cyanohydrins. The first part describes the development of a method for the synthesis of O‑alkoxycarbonylated and O-acylated cyanohydrins. READ MORE

5. 3. Enzyme selectivity as a tool in analytical chemistry

   Author : Anders Hamberg; Karl Hult; Harry Brumer; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; substrate specificity; competing substrates; enantiomeric excess analysis; library screening; ladder sequencing; carboxypeptidase Y; 2-pyridylmethylamine; MALDI; Candia antarctica lipase B; pig liver esterase; horse liver alcohol dehydrogenase; acylated cyanohydrins; Biochemistry; Biokemi;

   Abstract : Enzymes are useful tools as specific analytical reagents. Two different analysis methods were developed for use in the separate fields of protein science and organic synthesis. Both methods rely on the substrate specificity of enzymes. Enzyme catalysis and substrate specificity is described and put in context with each of the two developed methods. READ MORE

6. 4. Development and Studies of the Processes Involved in Minor Enantiomer Recycling

   Author : Anna Laurell Nash; Christina Moberg; Karl Anker Jørgensen; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; asymmetric catalysis; biocatalysis; cyanohydrins; dual activation; Lewis acid; Lewis base; minor enantiomer recycling; recycling; titanium; Kemi; Chemistry;

   Abstract : This thesis describes the development and rationalization of processes involved in a new methodology developed in our group, minor enantiomer recycling.The first part of the thesis addresses mechanistic studies of one of the reactions involved in minor enantiomer recycling, dual Lewis acid-Lewis base catalyzed acetylcyanation of aldehydes. READ MORE

7. 5. Serine Hydrolase Selectivity : Kinetics and applications in organic and analytical chemistry

   Author : Anders Hamberg; Karl Hult; Dick Janssen; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Candida antarctica lipase B; monoacylation of diols; kinetic resolution; thermodynamics in enzyme catalysis; enzyme engineering; Biochemistry; Biokemi;

   Abstract : The substrate selectivities for different serine hydrolases were utilized in various applications, presented in papers I-VI. The articles are discussed in the thesis in view of the kinetics of the enzyme catalysis involved. READ MORE