Search for dissertations about: "additivity."

Showing result 16 - 20 of 24 swedish dissertations containing the word additivity..

  2. 16. A first-principles approach to protein–ligand interaction

    Author : Pär Söderhjelm; Beräkningskemi; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; solvation; exchange repulsion; polarizable force fields; polarization; molecular mechanics; quantum chemistry; intermolecular interactions; protein–ligand interaction;

    Abstract : It is still impossible to make an accurate, purely theoretical prediction of the free energy of a ligand binding to a protein in aqueous environment. The two main problems are the immense number of nuclear configurations contributing to the binding free energy and the impossibility to apply accurate quantum-chemical methods to such a large system, even for a single configuration. READ MORE

  4. 17. Optimal design for dose-finding studies

    Author : Renata Eirini Tsirpitzi; Frank Miller; Kirsten Schorning; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bivariate model; distortion; drug combination; Elfving set; Emax model; Fedorov algorithm; mixed effects models; optimal experimental design; Statistics; statistik;

    Abstract : One of the most complex tasks during the clinical development of a new drug is to find a correct dose. Optimal experimental design has as a goal to find the best ways to perform an experiment considering the available resources and the statistical model. Optimal designs have already been used to determine the design of dose-finding studies. READ MORE

  5. 18. Binding of per- and polyfluoroalkyl substances (PFASs) in soil : effects of solution chemistry, soil properties, and PFAS structure

    Author : Hugo de Campos Pereira; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The large environmental mobility and persistence of per- and polyfluoroalkyl substances (PFASs) along with confirmed or suspected toxicities make the substances one of the great challenges of our time in the fields of chemical management and environmental risk assessment. In order to risk assess PFAS-contaminated sites, improved quantitative and mechanistic understanding of the partitioning and retention in soil is crucial. READ MORE

  6. 19. Studies of risk loci in multiple sclerosis

    Author : Magdalena Lindén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system, is one of the most common causes of neurological disability among young adults. While the etiology is unknown, an increasing number of environmental and genetic risk factors is being identified. READ MORE

  7. 20. Liver tumour promoting effects by polychlorinated biphenyls

    Author : Marie Haag Grönlund; Karolinska Institutet; Karolinska Institutet; []
    Keywords : tumour promotion; altered hepatic foci; rat liver; PCB; potency; TEF; interactions; antagonism; biologically based cancer growth models; TCDD;

    Abstract : PCBs cause a number of toxic effects and are present in a variety of biological samples including fish, meat and diary products. Cancer is a serious toxic effect by PCBs that has been observed in animal experiments but the knowledge about PCB induced carcinogenicity is still scarce. READ MORE