Search for dissertations about: "adenosine analogs"

Found 5 swedish dissertations containing the words adenosine analogs.

2. 1. DNA precursor biosynthesis-allosteric regulation and medical applications

   Author : Reza Rofougaran; Anders Hofer; Thomas Borén; Staffan Eriksson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; DNA biosynthesis; ribonucleotide reductase; allosteric regulation; Trypanosoma brucei; adenosine kinase; nucleoside analogs; mitochondrial DNA; TWINKLE; Biokemi; medicinsk biokemi; Medical Biochemistry;

   Abstract : Ribonucleotide reductase (RNR) is a key enzyme for de novo dNTP biosynthesis. We have studied nucleotide-dependent oligomerization of the allosterically regulated mammalian RNR using a mass spectrometry–related technique called Gas-phase Electrophoretic Mobility Macromolecule Analysis (GEMMA). READ MORE

4. 2. Adenosine action on platelets : pharmacological and functional studies in human platelets in vitro

   Author : Ulla Söderbäck; Karolinska Institutet; Karolinska Institutet; []
   Keywords : adenosine; adenosine analogs; methylxanthines; cyclic AMP; ADP; dipyridamole; platelet-rich plasma; whole blood aggregatron; human. Ulla SöderbäckAdenosine action on platelets. Pharmacological and functional studies in human pl;

   Abstract : The endogenous purine adenosine (ADO) is known to inhibit platelet aggregation in vitro through increased platelet levels of cyclic AMP. This effect is ADO-A2-receptor-mediated through stimulation of membrane adenylyl cyclase. READ MORE

5. 3. Salvage and de novo synthesis of nucleotides in Trypanosoma brucei and mammalian cells

   Author : Artur Fijolek; Lars Thelander; Arne Holmgren; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; nucleotides; ribonucleotide reductase; Ara-A; p53R2; Trypanosoma brucei; African sleeping sickness; trypanosomiasis; CTP synthetase; adenosine kinase; acivicin; adenine arabinoside; Biochemistry; Biokemi;

   Abstract : All living cells are dependent on nucleic acids for their survival. The genetic information stored in DNA is translated into functional proteins via a messenger molecule, the ribonucleic acid (RNA). Since DNA and RNA can be considered as polymers of nucleotides (NTPs), balanced pools of NTPs are crucial to nucleic acid synthesis and repair. READ MORE

6. 4. Targeting the nucleotide metabolism of the mammalian pathogen Trypanosoma brucei

   Author : Munender Vodnala; Anders Hofer; Arne Holmgren; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Trypanosoma brucei; adenosine kinase; thymidine kinase; methylthioadenosine phosphorylase; mouser ribonucleotide reductase; E. coli ribonucleotide reductase; RNR; Ara-A; F-Ara-A; dNTP; NTP; doexynucleotide metabolism; nucleosides; nucleoside kinases; allosteric regulation; biologisk kemi; biological chemistry;

   Abstract : Trypanosoma brucei causes African sleeping sickness in humans and Nagana in cattle. There are no vaccines available against the disease and the current treatment is also not satisfactory because of inefficacy and numerous side effects of the used drugs.T. READ MORE

7. 5. Novel treatment of African trypanosomiasis

   Author : Suman Kumar Vodnala; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Human African Trypanosomiasis (HAT) or Sleeping Sickness is fatal if untreated. Current drugs used for the treatment of HAT have difficult treatment regimens and unacceptable toxicity related issues. READ MORE