Search for dissertations about: "adenosine receptor"

Showing result 6 - 10 of 79 swedish dissertations containing the words adenosine receptor.

  2. 6. Behavioural and biochemical pharmacology of adenosine/dopamine receptor/receptor interaction

    Author : Roberto Rimondini-Giorgini; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Adenosine; A; receptors; A2A receptors; dopamine; D1 receptors; D2 receptors; mGluR receptors; striatum; immediately early genes; c-fos; junB; NGFI-A; microdialysis; receptor binding; in situ hybridisation;

    Abstract : The neurotransmitter dopamine seems to be involved in neuropsychiatric diseases such as schizophrenia and Parkinson's disease. Direct blockade of dopamine receptors of the D2 subtype has been the hallmark of pharmacotherapy for schizophrenia since early 1950s. READ MORE

  4. 7. Myocardial energy metabolism in ischemic preconditioning, role of adenosine catabolism

    Author : Mohammad Kavianipour; Umeå universitet; []
    Keywords : Ischemic preconditioning; adenosine; purine nucleoside phosphorylase; microdialysis; pig; Medicine; medicin;

    Abstract : Brief episodes of ischemia and reperfusion render the myocardium more resistant to necrosis from a subsequent, otherwise lethal ischemic insult. This phenomenon is called ischemic preconditioning(IP). READ MORE

  5. 8. Development and Characterization of a Global Brain Ischemia Model in the Mouse -A Genetic and Pharmacological Approach

    Author : Tomas Olsson; Neuroinflammation; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neurofysiologi; neuropsykologi; Neurologi; neuropsychology; Neurology; global; hypothermia; hsp70; receptor; adenosine A1; NMDA; cystatin C; cell death; hippocampus; Brain; ischemia; neurophysiology;

    Abstract : Brain ischemia is a major cause of death and morbidity in the industrialized countries. It is mainly caused by stroke, but may also be the consequence of successful cardiopulmonary resuscitation in victims of cardiac arrest, known as transient global ischemia. READ MORE

  6. 9. Advances in Ligand Binding Predictions using Molecular Dynamics Simulations

    Author : Henrik Keränen; Johan Åqvist; Jordi Villà i Freixa; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; free-energy perturbation; molecular dynamics; ligand binding; free-energy perturbation; linear interaction energy; binding free-energy; homology modeling; virtual screening; alanine scanning; amino acid mutagenesis; hERG; GPCR; adenosine receptor; serotonin receptor; BRICHOS; cruzain;

    Abstract : Biochemical processes all involve associations and dissociations of chemical entities. Understanding these is of substantial importance for many modern pharmaceutical applications. In this thesis, longstanding problems with regard to ligand binding are treated with computational methods, applied to proteins of key pharmaceutical importance. READ MORE

  7. 10. Interaction between Adenosine and Angiotensin II in Renal Afferent Arterioles of Mice

    Author : Enyin Lai; A. Erik G. Persson; Göran Bergström; Uppsala universitet; []
    Keywords : Physiology; adenosine; angiotensin II; afferent arteriole; calcium; nitric oxide; microperfusion; tubuloglomerular feedback; Fysiologi;

    Abstract : Renal arterioles represent the most important effecter site in the control of renal perfusion and filtration. Adenosine (Ado), angiotensin II (Ang II) and nitric oxide (NO) interact in modulating arteriolar tone. The present work investigates the mechanism of this interaction. READ MORE