Search for dissertations about: "adenovirus"

Showing result 16 - 20 of 143 swedish dissertations containing the word adenovirus.

  2. 16. Adenovirus species B interactions with CD46

    Author : Dan Gustafsson; Ya-Fang Mei; Urs Greber; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Adenovirus 11; CD46; mikrobiologi; Microbiology;

    Abstract : Adenoviruses (Ad) are double-stranded (ds) DNA, non-enveloped viruses. There are seven species (A-G) of human Ads with 52 knownserotypes to date. Human Ads cause a broad range of pathologies, ranging from upper respiratory tract infections to persistent urinary tract infections. READ MORE

  4. 17. Challenges in the treatment of malignant glioma with oncolytic adenovirus

    Author : Johan Rebetz; Lund Pediatrik; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Glioma; Adenovirus; Fiber; Cancer stem cells;

    Abstract : Malignant glioma is a tumor that spreads rapidly throughout brain and is almost impossible to remove completely by surgery. It is resistant to chemo- and radiotherapy and the prognosis is very poor. As a result, there is a desperate need for development of novel therapies against this devastating disease. READ MORE

  5. 18. Modulation of Adenovirus E1A Activities by the Cellular Corepressor CtBP

    Author : Cecilia Johansson; Catharina Svensson; Laszlo Szekely; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Adenovirus; E1A; CtBP; transcription regulation; TetON; microarray; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Abstract : Adenovirus E1A is needed to activate early viral genes and induce cell cycle progression to optimise the conditions for viral replication. This is mostly achieved through interactions between the first exon of E1A and cellular transcriptional regulatory proteins. READ MORE

  6. 19. Replication-competent adenovirus 11p vector as a new oncolytic agent

    Author : Jim Silver; Ya-Fang Mei; Gunnel Halldén; Umeå universitet; []
    Keywords : Virologi; Adenovirus; Vector; mikrobiologi; Microbiology;

    Abstract : Human adenoviruses (Ads) as vectors have been studied for cancer gene therapy for several decades due to their ability to shut down host cell replication and lyse tumour cells. Ad5 of species C is commonly used as a replication-defective or a replication-competent vector. READ MORE

  7. 20. Glycoconjugates : synthesis and investigation of carbohydrate-protein interactions

    Author : Sara Spjut; Mikael Elofsson; Ulf Ellervik; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugates; Carbohydrates; Galactose; Glucose; Solid-phase synthesis; SPOS; Glycosylation; Gel-phase 19F NMR spectroscopy; Fluorinated linker; Carbohydrate array; Microtiter plates; Carbohydrate-protein interactions; carbamate linker; Fsec; Protecting group; Fluorinated protecting group; Multivalent glycoconjugates; Adenovirus; Ad37; Epidemic keratoconjunctivitis; EKC; Sialic acid; Adenovirus inhibitor; Trivalent; Tetravalent; X-ray crystal structure; Bioorganic chemistry; Bioorganisk kemi; organisk kemi; Organic Chemistry;

    Abstract : To study the functions of glycoconjugates in biological systems reliable and efficient protocols for glycoconjugate synthesis are needed. To reach this goal we have developed methods for solid-phase synthesis of glycoconjugates that can be monitored with gel-phase 19F spectroscopy using fluorinated linkers, building blocks, and protecting groups. READ MORE