Search for dissertations about: "adenylyl cyclase AC"

Showing result 1 - 5 of 6 swedish dissertations containing the words adenylyl cyclase AC.

  2. 1. Alpha-2 Adrenergic Receptors and Signal Transduction : Effector Output in Relation to G-Protein Coupling and Signalling Cross-Talk

    Author : Johnny Näsman; Peter Evans; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Adrenergic; receptor; G-protein; adenylyl cyclase; cAMP; calcium; cross-talk; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

    Abstract : The alpha-2 adrenergic receptor (α2-AR) subfamily includes three different subtypes, α2A-, α2B- and α2C-AR, all believed to exert their function through heterotrimeric Gi/o-proteins. The present study was undertaken in order to investigate subtype differences in terms of cellular response and to explore other potential signalling pathways of α2-ARs. READ MORE

  4. 2. G-proteins and adenylyl cyclase in Alzheimer's disease postmortem brain

    Author : Angela Garcia-Jimnez; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer's disease (AD) is the most common type of dementia in the elderly. The major pathological changes seen in the disease are the formation of neurofibrillary tangles, of which the main component is the hyperphosphorylated form of tau, and the over accumulation of plaques formed by beta-amyloid. READ MORE

  5. 3. Mechanisms of impaired insulin release in type-2 diabetes : studies in the GK rat model

    Author : Amel Guenifi; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Goto-Kakizaki GK rat; Type-2 diabetes; insulin secretion; morphometry; adenylyl cyclase AC ; phospholipase-C PLC ; ß-cell;

    Abstract : Type-2 diabetes is a complex syndrome with a polygenic and multifactorial aetiology. It is characterised by its relatively late appearance in life and its mild progressive course. Glucose intolerance can generally be ascribed to disturbed pancreatic hormonal secretion and/or insulin resistance in the liver and extrahepatic tissues. READ MORE

  6. 4. Cyclic nucleotide signalling in Alzheimer's disease postmortem brain

    Author : Willy Lokwa Bonkale; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The aim of this study was to determine the nature and significance of altered guanylyl cyclase (GC) and adenylyl cyclase (AC) signalling in Alzheimer's disease (AD) postmortem brain. Paper I describes a study of particulate and soluble GC activities in postmortem temporal cortex from a series of AD and matched control subjects. READ MORE

  7. 5. Regulatory importance of cyclic nucleotides in smooth muscle growth of the urogenital tract

    Author : Per Adolfsson; Thoralf Christoffersen; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Smooth muscle hyperplasia/hypertrophy is, if not responsible for, so at least involved in those diseases, which impair life quality for most people in today's society.This thesis, presents a pharmacological investigation, related to the regulatory role of cyclic nucleotides, of smooth muscle hyperplasia/hypeitrophy in human uterine leiomyoma and benign prostate hyperplasia (BPH). READ MORE