Search for dissertations about: "adenylyl cyclases"

Showing result 1 - 5 of 6 swedish dissertations containing the words adenylyl cyclases.

  2. 1. Signaling via Orexin Receptors : A Pharmacological Study

    Author : Tomas Holmqvist; Jyrki Kukkonen; Karl Åkerman; Gunnar Flemström; Per Svenningsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; orexin; receptors; calcium; cAMP; adenylyl cyclases; Fysiologi; Physiology; Fysiologi;

    Abstract : The orexin receptors are a pair of newly discovered G-protein coupled receptors which are activated by the neuropeptides orexins and play a role in sleep/vigilance, apetite/metabolism and neuroendocrine regulation. On a cellular level receptor activation results in, to name but a few effects, elevation of intracellular calcium and depolarisation. READ MORE

  4. 2. Studies of cAMP and Ca2+ signaling in pancreatic islet cells

    Author : Hongyan Shuai; Anders Tengholm; Erik Gylfe; Sebastian Barg; Albert Salehi; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreatic islet; insulin; glucagon; somatostatin; pancreatic polypeptide; exendin- 9-39 ; GLP-1; GIP; ATP; adenosine; cAMP; Ca2 ; β-cell; α-cell; δ-cell; PP-cell;

    Abstract : The blood glucose-lowering and -elevating hormones insulin and glucagon are released from the pancreatic islet β- and α-cells, respectively. The intracellular messengers Ca2+ and cAMP have central roles in controlling the secretion of both hormones, but the underlying mechanisms are incompletely understood. READ MORE

  5. 3. Cyclic AMP Oscillations in Insulin-Secreting Cells

    Author : Jenny Sågetorp; Anders Tengholm; Erik Gylfe; Lena Stenson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical cell biology; Medicinsk cellbiologi;

    Abstract : Cyclic AMP is an intracellular messenger that regulates numerous processes in various types of cells. In pancreatic β-cells, cAMP potentiates the secretion of insulin by promoting Ca2+ signals and by amplifying Ca2+-triggered exocytosis. Whereas Ca2+ signals have been extensively characterized, little is known about the kinetics of cAMP signals. READ MORE

  6. 4. Oscillatory Signaling and Insulin Secretion from Single ß-cells

    Author : Olof Idevall Hagren; Anders Tengholm; Erik Gylfe; Leslie Satin; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP; Ca2 ; oscillations; beta-cell; insulin secretion; evanescent wave microscopy; PIP3; PKA; Epac; Medical cell biology; Medicinsk cellbiologi; Medical Cell Biology; Medicinsk cellbiologi;

    Abstract : cAMP and Ca2+ are key regulators of exocytosis in many cells, including insulin-secreting pancreatic β-cells. Glucose-stimulated insulin secretion from β-cells is pulsatile and driven by oscillations of the cytoplasmic Ca2+ concentration ([Ca2+]i), but little is known about the kinetics of cAMP signaling and the mechanisms of cAMP action. READ MORE

  7. 5. The Role of Phosphodiesterase 3B in the Regulation of Insulin Secretion

    Author : Linda Härndahl; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; Endokrinologi; sekretion; diabetologi; secreting systems; Endocrinology; beta-cell; diabetes; islet; PDE3B; cAMP;

    Abstract : Pancreatic beta-cell dysfunction and insulin resistance are the two hallmarks of type 2 diabetes. An early sign of beta-cell dysfunction is impaired nutrient-induced insulin release. Several insulin secretagogues act by increasing the formation of intracellular cAMP. READ MORE