Search for dissertations about: "adjuvant induced arthritis"

Showing result 1 - 5 of 27 swedish dissertations containing the words adjuvant induced arthritis.

2. 1. Pathogenetic studies of adjuvant-induced arthritis

   Author : Barbro Holm; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Adjuvant-induced arthritis; squalene; Incomplete Freunds Adjuvant; QTL; lymph nodes; inflammation;

   Abstract : Rheumatoid arthritis (RA) is a disabling chronic inflammatory disease, presumably autoimmune, that progressively destroys peripheral joints. The etiopathogenesis remains largely unknown, and an understanding of disease mechanisms and identification of genes is rendered difficult due to the multifactorial influence on RA. READ MORE

4. 2. Immunomodulation of collagen-induced arthritis

   Author : Lars Mattsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : autoimmunity; arthritis; collagen type II; immunomodulation; vitamin D; parasite;

   Abstract : Collagen-induced arthritis (CIA) is an experimental autoimmune disease sharing many features with human rheumatoid arthritis (RA). CIA development is dependent on T-cells but anti-collagen type II (anti-CII) antibody production by B-cells is also important. READ MORE

5. 3. Immunologic and genetic studies of rat adjuvant-induced arthritis

   Author : Åsa Jansson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : arthritis; autoimmunity; adjuvant; incomplete Freund s adjuvant; squalene; quantitative trait locus;

   Abstract : Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with a multifactorial and largely unknown etiology. It is influenced by both environmental and genetic factors, and understanding of disease mechanisms and identification of disease-causing genes is hampered by the complex and polygenic nature of the disease. READ MORE

6. 4. Modulation of immune responses in murine collagen induced arthritis

   Author : Fredrik Bäckström; Göteborgs universitet; []
   Keywords : Experimental arthritis; type II collagen; immunomodulation; oral tolerance;

   Abstract : Murine collagen-induced arthritis (CIA) is the most common model for studying human rheumatoid arthritis (RA). Autologous or heterologous type II collagen (CII) emulsified in Freund´s complete adjuvant induces arthritis in susceptible mice, which is histopathologically similar to RA. READ MORE

7. 5. Studies on immunological mechanisms of induced arthritis in the rat

   Author : Lena Svelander; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Arthritis; autoimmunity; adjuvant; incomplete Freund s adjuvant; squalene; CpG;

   Abstract : Experimental arthritis induced with adjuvants shares many features with the human autoimmune disorder rheumatoid arthritis (RA). The use of arthritis models is therefore a relevant approach in the search for pathogenic mechanisms in human disease. READ MORE