Search for dissertations about: "adoptive T cell therapy"
Showing result 11 - 15 of 20 swedish dissertations containing the words adoptive T cell therapy.
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11. MHC class I restricted and antigen-specific TCRs against viral and tumor-associated antigens (TAAs) for future biological therapy
Abstract : Adoptive cellular immunotherapy (ACT) refers to the process of transferring immune cells (autologous or allogeneic) directly to the host as a treatment for cancer or infectious diseases. The effector cells could be antigen-specific, like T cells, or non-specific, such as NK cells or lymphokine-activated killer (LAK) cells. READ MORE
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12. Immunological recognition and tumor escape mechanisms of ovarian carcinoma
Abstract : Ovarian carcinoma is a leading cause of cancer mortality and there is an urgent need for new and better therapeutic modalities that result in improved long-term outcome for this severe malignancy. One promising treatment modality for patients suffering from ovarian carcinoma is immunotherapy. READ MORE
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13. Natural killer cells in cancer : studies on migration and cytotoxicity
Abstract : The role of natural killer (NK) cells in cancer development has been studied extensively over the last four decades and the increasing knowledge on NK cell regulation has improved both safety and efficacy of treatment. Despite these recent advances the clinical success has to date been modest in treatment of solid tumors, owing both to suboptimal directed migration of NK cells and the tumor cell’s resistance to NK cell-mediated lysis. READ MORE
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14. On lymph node based immunotherapy of cancer
Abstract : Cancer Immunotherapy based on one’s own immune system to fight cancer is emerging as an important treatment option for advanced stage diseases. The earliest attempts of cancer therapy based on the provocation of the immune system with infectious agents can be traced back to the 18th century, and the field of immunotherapy has since developed into three main groups: cellular-, antibody- and cytokine- therapies. READ MORE
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15. Cellular and personalized therapies in multiple myeloma with special emphasis on retargeted natural killer cells
Abstract : Multiple myeloma (MM) is a clonal plasma cell malignancy accounting for approximately 10% of all hematological cancer cases. Despite considerable advances in MM management, which led to exceptional response and survival rates, patients still experience relapse and cure remains elusive. READ MORE