Search for dissertations about: "adrenocorticolytic compounds"

Found 2 swedish dissertations containing the words adrenocorticolytic compounds.

2. 1. Toxicologically important DDT metabolites : Synthesis, enantioselective analysis and kinetics

   Author : Tatiana Cantillana; Åke Bergman; Peter Sundin; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; o; p -DDD; 3-Methylsulfonyl-DDE; adrenocorticolytic compounds; chiral; Environmental chemistry; Miljökemi; Environmental Chemistry; miljökemi;

   Abstract : DDT was extensively and globally used as a pesticide in agriculture and for malaria vector control from the 1940’s until the 1970’s. Due to its heavy use, DDT became ubiquitously distributed throughout the environment. DDT and several DDT metabolites are persistent organic pollutants. READ MORE

4. 2. In Vitro Studies of Adrenocorticolytic DDT Metabolites, with Special Focus on 3-methylsulfonyl-DDE

   Author : Vendela Asp; Ingvar Brandt; Ulrika Bergström; Olle Söder; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicity; 3-methylsulfonyl-DDE; CYP; adrenal cortex; metabolic activation; steroid hormones; Y-1; H295R; mitotane; adrenocortical carcinoma; Toxicology; Toxikologi; Biologi med inriktning mot ekotoxikologi; Biology with specialization in Environmental Toxicology;

   Abstract : The DDT metabolite 3-methylsulfonyl-DDE (3-MeSO2-DDE) is bioactivated by cytochrome P450 11B1 (CYP11B1) in the adrenal cortex of mice and forms irreversibly bound protein adducts, reduces glucocorticoid secretion, and induces cell death selectively in cortisol-producing adrenocortical cells. 3-MeSO2-DDE has therefore been proposed as a lead compound for an improved adrenocortical carcinoma (ACC) therapy. READ MORE