Search for dissertations about: "adult stem cell"

Showing result 1 - 5 of 216 swedish dissertations containing the words adult stem cell.

  1. 1. Hematopoietic stem and progenitor cells and potentials for application in fetal cell replacement therapy

    University dissertation from Department of Obstetrics and Gynecology, Lund University

    Author : Karina Liuba; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; in utero hematopoietic cell transplantation; hematopoietic stem cell; multipotent progenitor; fetal therapy; heterotypic cell fusion;

    Abstract : Fetal cell replacement therapy or in utero hematopoietic cell transplantation (IUHCT) is proposed as a non-myeloablative alternative to bone marrow transplantation (BMT) for a number of inborn immunologic, hematologic and metabolic disorders. IUHCT represents the method through which variable amounts of natural or genetically modified hematopoietic cells can be transferred to the fetal recipient in hope of correcting the disorder and preventing postnatal permanent organ damage. READ MORE

  2. 2. Regulation of Hematopoietic Stem and Progenitor Cells by Bone Marrow Niche Components

    University dissertation from Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy

    Author : Hong Qian; Lund University.; Lunds universitet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stem cell; Hematologi; extracellular fluids; Haematology; bone marrow; Hematopoiesis; extracellulära vätskor;

    Abstract : Throughout the lifespan of an individual, enormous numbers of mature blood cells are generated by hematopoietic stem cells (HSCs) in the bone marrow (BM). The HSC is a cell that can self-renew to maintain the HSC pool and differentiate into all types of mature blood cells. READ MORE

  3. 3. Cardiomyocyte Cell Cycle, Renewal and Isolation

    University dissertation from Cardiovascular Laboratory, Center for Stem Cell Biology, Lund

    Author : Stuart Walsh; Lund University.; Lunds universitet.; [2010]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; binucleation; Cardiomyocytes; surface marker; troponin-T; mitosis; microarray; cell cycle; FACS;

    Abstract : Heart disease results from the loss of cardiomyocytes following myocardial damage and is a leading cause of death worldwide. Stimulating the endogenous regeneration of cardiomyocytes or isolating them from in vitro culture is an attractive therapeutic strategy. READ MORE

  4. 4. Maf transcription factors in beta cell function

    University dissertation from Stem Cell Center, Lund University

    Author : Elvira Ganic; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Beta cell; MafA; type 2 diabetes; insulin secretion; transcription; monoamine oxidase; MaoA; MaoB; nicotinic receptor subunits; nAChRs;

    Abstract : Diabetes mellitus is metabolic disorder caused by a defect or lack of beta cell-produced insulin that controls blood glucose homeostasis. In addition to glucose, insulin secretion is regulated by the autonomic nervous system (ANS); the neurotransmitter acetylcholine as well as monoamines, such as dopamine, serotonin, melatonin and norepinephrine. READ MORE

  5. 5. Maf and Mitf transcription factors regulate pancreatic endocrine cell differentiation and function

    University dissertation from Stem Cell Center, Lund University

    Author : Magdalena Mazur; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pancreas development; beta cells; insulin; MafA; MafB; Mitf; diabetes;

    Abstract : Diabetes - the imbalance in glucose homeostasis is partially caused by loss or dysfunction of pancreatic insulin producing β cells or development of insulin resistance. In Type 1 diabetes β cells are destroyed in the process of an autoimmune attack, whereas in Type 2 diabetes, islets produce insufficient amounts of insulin or the insulin cannot be used adequately. READ MORE