Search for dissertations about: "adverse predict"

Showing result 21 - 25 of 109 swedish dissertations containing the words adverse predict.

2. 21. Platelet Inhibition and Bleeding in Coronary Artery Bypass Surgery

   Author : Ulrica Alström; Elisabeth Ståhle; Ulf Schött; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; bleeding; cardiac surgery; platelet inhibition; re-exploration; cost analysis; Anaesthetics and intensive care; Anestesiologi och intensivvård; Thoraxkirurgi; Thorax Surgery; Anaesthesiology and Intensive Care; Anestesiologi och intensivvård;

   Abstract : A substantial number of patients undergoing cardiac surgery are on dual anti-platelet treatment with clopidogrel and aspirin. A disadvantage with this treatment is increased risk of bleeding. Bleeding is a complication of major concern associated with adverse outcome for the patient and increased hospital resource utilization. READ MORE

4. 22. Predicting clinical outcomes via machine learning on electronic health records

   Author : Awais Ashfaq; Sławomir Nowaczyk; Jerker Westin; Högskolan i Halmstad; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : The rising complexity in healthcare, exacerbated by an ageing population, results in ineffective decision-making leading to detrimental effects on care quality and escalates care costs. Consequently, there is a need for smart decision support systems that can empower clinician's to make better informed care decisions. READ MORE

5. 23. Mechanistic Based Pharmacokinetic-Pharmacodynamics models for Drug Interactions and Disease Population Predictions

   Author : Luna Prieto Garcia; Erik Sjögren; Aleksandra Galetin; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiologically-Based Pharmacokinetics; Pharmacokinetics; Pharmacodynamics; Disease Modelling; Drug Interactions; Statins; Mechanistic Modelling; Farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

   Abstract : Therapeutic dose of a medication refers to the quantity of a drug required to produce a pharmacological effect without causing unacceptable adverse events. Dose selection in the clinical setting is not straight forward due to various factors, including specific patient factors such as age, sex, weight, genetic variants and renal/hepatic function, as well as external factors such as food and co-medication, all of which can influence the efficacy and safety of a drug. READ MORE

6. 24. Quantitative Clinical Pharmacological Studies on Efavirenz and Atazanavir in the Treatment of HIV-1 Infection

   Author : Dinko Rekić; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV; Pharmacokinetics; Pharmacodynamics; Pharmacometrics; AIDS;

   Abstract : There are 34 million people infected with the HIV-1 virus in the world today. Due to increased access to antiretroviral therapy, AIDS related death has dropped by 30% since 2005. READ MORE

7. 25. Pharmacometrics to improve clinical benefit assessment in oncology

   Author : Emilie Schindler; Lena E Friberg; Mats O Karlsson; Rik de Greef; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed effect models; NONMEM; pharmacokinetics; pharmacodynamics; VEGF; SLD; targeted therapies; IRT; FDG-PET; SUVmax; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : The high attrition rate in oncology drug development calls for new approaches that would increase the understanding of drugs’ efficacy and safety profiles. This thesis focuses on the development of pharmacometric models to characterize and quantify the relationships between drug exposure, circulating and imaging biomarkers, adverse effects, overall survival (OS), and patient-reported outcomes (PROs). READ MORE