Search for dissertations about: "affected sib-pair"

Found 5 swedish dissertations containing the words affected sib-pair.

  2. 1. On Power Estimation and Score Predictions in Affected Sib-Pair Linkage Analysis

    Author : Mikael Knutsson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; affected sib-pair; linkage analysis; nonparametric linkage score; sib prevalence; statistical genetics; nonparametric linkage score;

    Abstract : This thesis consists of three papers in statistical genetics, with the emphasis on affected sib-pair linkage analysis. In Paper A, a method to derive the power of linkage analysis in genome scans, using a stepwise approach, is presented. READ MORE

  4. 2. Two-Locus affected sib-pair identity by descent probabilities

    Author : Olof Bengtsson; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : .... READ MORE

  5. 3. Identifying Risk Genes for Cervical Cancer : Using Affected Sib-Pairs and Case-Control Materials from Sweden

    Author : Malin Engelmark; Ulf Gyllensten; Dan Holmberg; Uppsala universitet; []
    Keywords : Medicine; Cervical cancer; HPV; Affected sib-pairs; HLA; Fas; Genomewide scan; 9q32; TSCOT; Medicin;

    Abstract : Cervical cancer is a multifactorial disease. Infection by oncogenic types of the human papillomavirus (HPV) is the major environmental risk factor and host genetic susceptibility also influences disease development. The aim of this thesis is to identify and analyse risk genes involved in the genetic predisposition to cervical carcinoma. READ MORE

  6. 4. Multiple sclerosis linkage analysis and DNA variation in a complex trait

    Author : Helena Modin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple sclerosis is a life-long disease affecting approximately 11.000 individuals in Sweden today. It is the second most common cause of neurological disability amongst young adults, only outnumbered by traffic accidents. Genetic epidemiological studies indicate that genetic factors contribute to the susceptibility of MS. READ MORE

  7. 5. Linkage and association analysis in multiple sclerosis

    Author : Yamei Dai; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, which is characterized by relapsing or progressive demyelinating plaques in the brain and spinal cord. It is well established that complex genetic factors influence susceptibility to MS. READ MORE