Search for dissertations about: "affibody molecule"

Showing result 16 - 20 of 60 swedish dissertations containing the words affibody molecule.

  2. 16. On the Design of Affibody Molecules for Radiolabeling and In Vivo Molecular Imaging

    Author : Daniel Rosik; Amelie Eriksson Karlström; Christian Heinis; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Affibody molecule; AC DC; radionuclide molecular imaging; HER2; SPECT; PET; biodistribution; peptide synthesis; radiolabeling; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

    Abstract : Affibody molecules have lately shown great potential as tools for in vivo molecular imaging. These small, 3-helical bundles, with their highly stable protein scaffold, are well suited for the often harsh conditions of radiolabeling. READ MORE

  4. 17. Tumor targeted delivery of cytotoxic payloads using affibody molecules and ABD-derived affinity proteins

    Author : Hao Liu; Torbjörn Gräslund; Stefan Ståhl; Nick Devoogdt; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Targeted tumor therapy; immunotoxins; ADCs; affibody molecule; ADAPT; pseudomonas exotoxin A; maytansinoid; Bioteknologi; Biotechnology;

    Abstract : Cancer treatment cost billions of dollars every year, but the mortality rate is still high. An ideal treatment is the so-called “magic bullets” that recognize and kill tumor cells while leaving normal cells untouched. READ MORE

  5. 18. HER2-receptor quantification in breast cancer patients by imaging with ABY-025 Affibody and PET

    Author : Ali Alhuseinalkhudhur; Henrik Lindman; Jens Sörensen; Mark Lubberink; Irina Velikyan; Rimma Axelsson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PET; Breast cancer; HER2; Affibody; ABY-025; Molecular imaging; Kinetic modelling; Brain metastasis;

    Abstract : Breast cancer is the most common malignancy in women worldwide. Human epidermal growth factor receptor type 2 (HER2) is overexpressed in up to 20% of breast cancer cases and is considered an important prognostic factor and a therapeutic target. READ MORE

  6. 19. Generation and characterization of Affibody molecules targeting HER3

    Author : Magdalena Malm; Stefan Ståhl; Jennifer Cochran; KTH; []
    Keywords : Affibody molecules; epidermal growth factor receptors; HER3; ErbB3; combinatorial protein engineering; combinatorial library; staphylococcal surface display;

    Abstract : In the field of oncology, the ability to target specific tumor cells using highly selective targeting molecules is an attractive and emerging concept. In this context, the epidermal growth factor receptor HER3 has proven central to the biology behind many different human cancers and inhibition of the signaling mediated by this receptor could provide antitumoral effects. READ MORE

  7. 20. Radiolabelled affibody molecules for imaging EGFR expression in tumours

    Author : Maryam Oroujeni; Vladimir Tolmachev; Martin Behe; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Affibody molecules; ZEGFR:2377; radionuclide molecular imaging; PET; SPECT; labelling chemistry.;

    Abstract : Affibody molecules are promising scaffold-based targeting proteins for radionuclide imaging and cancer therapy. This thesis is based on 5 original research articles (Papers I-V), with the primary focus being placed on the optimization of molecular design of EGFR-binding affibody variants for high contrast imaging of epidermal growth factor receptor (EGFR) expression in tumours. READ MORE