Search for dissertations about: "affibody"

Showing result 1 - 5 of 89 swedish dissertations containing the word affibody.

2. 1. Targeting Human Epidermal Growth Factor Receptors with Drug Conjugates Based on Affibody Molecules

   Author : Jie Zhang; Torbjörn Gräslund; Per-Åke Nygren; Marika Nestor; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody molecule; HER2; HER3; affibody-drug conjugate; half-life; payload; Affibody-molekyl; HER2; HER3; affibody-läkemedelskonjugat; halveringstid; nyttolast; Biotechnology; Bioteknologi;

   Abstract : Cancer is a major public health challenge and the second leading cause of death in the world, with millions of new cases being diagnosed each year. Traditional cancer treatments such as surgery, radiation therapy, and chemotherapy are many times effective, but may also cause damage to healthy cells, leading to side effects. READ MORE

4. 2. Affibody molecules for proteomic and therapeutic applications

   Author : Caroline Grönwall; Stefan Ståhl; Lena Jendeberg; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody; protein engineering; phage display; amyloid beta peptide; transferrin; CD25; IL-2 receptor; proteomics; Bioengineering; Bioteknik;

   Abstract : This thesis describes generation and characterization of Affibody molecules with future applications in proteomics research, protein structure determinations, therapeutic treatment of disease and medical imaging for in vivo diagnostics. Affibody molecules are engineered affinity proteins developed by combinatorial protein engineering from the 58-residue protein A-derived Z domain scaffold. READ MORE

5. 3. Cellular Studies of HER-family Specific Affibody Molecules

   Author : Lovisa Göstring; Lars Gedda; Jörgen Carlsson; Fredrik Frejd; Håkan Hedman; Uppsala universitet; []
   Keywords : EGFR; HER2; HER3; Affibody; internalisation; tumour targeting; MEDICINE; MEDICIN;

   Abstract : The human epidermal growth-factor like receptor (HER) family of receptor tyrosine kinases are important targets for cancer therapy. The family consists of four members - EGFR, HER2, HER3 and HER4 - that normally transfer stimulatory signals from extracellular growth factors to the intracellular signalling network. READ MORE

6. 4. Radiolabeled HER-2 Binding Affibody Molecules for Tumor Targeting : Preclinical Studies

   Author : Ann-Charlott Steffen; Jörgen Carlsson; Vladimir Tolmachev; Lars Gedda; Ragnar Hultborn; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; HER-2; affibody; 211At; tumor targeting; targeted radiotherapy; molecular imaging; Biomedicin; Microbiology; Mikrobiologi;

   Abstract : Conventional cancer treatment based on radiotherapy or chemotherapy affects all dividing cells. By directing the therapy specifically to the tumor cells, normal cells can be spared. Tumor targeting molecules carrying a cytotoxic moiety is then an attractive approach. READ MORE

7. 5. Ribosome display for selection and evolution of affibody molecules

   Author : Sebastian Grimm; Per-Åke Nygren; Mike Taussig; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; ribosome display; phage display; combinatorial protein engineering; library; murine IgG1; SATB1; Ras; Raf; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

   Abstract : Affinity proteins are invaluable tools in biotechnological and medical applications. This thesis is about combinatorial protein engineering principles for the generation of novel affinity proteins to purify mouse immunoglobulin, detect a potential cancer marker protein or inhibit a cell proliferation pathway. READ MORE