Search for dissertations about: "affibody"

Showing result 1 - 5 of 84 swedish dissertations containing the word affibody.

  2. 1. Affibody molecules for proteomic and therapeutic applications

    Author : Caroline Grönwall; Stefan Ståhl; Lena Jendeberg; KTH; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; Affibody; protein engineering; phage display; amyloid beta peptide; transferrin; CD25; IL-2 receptor; proteomics; Bioengineering; Bioteknik;

    Abstract : This thesis describes generation and characterization of Affibody molecules with future applications in proteomics research, protein structure determinations, therapeutic treatment of disease and medical imaging for in vivo diagnostics. Affibody molecules are engineered affinity proteins developed by combinatorial protein engineering from the 58-residue protein A-derived Z domain scaffold. READ MORE

  4. 2. Cellular Studies of HER-family Specific Affibody Molecules

    Author : Lovisa Göstring; Lars Gedda; Jörgen Carlsson; Fredrik Frejd; Håkan Hedman; Uppsala universitet; []
    Keywords : EGFR; HER2; HER3; Affibody; internalisation; tumour targeting; MEDICINE; MEDICIN;

    Abstract : The human epidermal growth-factor like receptor (HER) family of receptor tyrosine kinases are important targets for cancer therapy. The family consists of four members - EGFR, HER2, HER3 and HER4 - that normally transfer stimulatory signals from extracellular growth factors to the intracellular signalling network. READ MORE

  5. 3. Radiolabeled HER-2 Binding Affibody Molecules for Tumor Targeting : Preclinical Studies

    Author : Ann-Charlott Steffen; Jörgen Carlsson; Vladimir Tolmachev; Lars Gedda; Ragnar Hultborn; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomedicine; HER-2; affibody; 211At; tumor targeting; targeted radiotherapy; molecular imaging; Biomedicin; Microbiology; Mikrobiologi;

    Abstract : Conventional cancer treatment based on radiotherapy or chemotherapy affects all dividing cells. By directing the therapy specifically to the tumor cells, normal cells can be spared. Tumor targeting molecules carrying a cytotoxic moiety is then an attractive approach. READ MORE

  6. 4. Ribosome display for selection and evolution of affibody molecules

    Author : Sebastian Grimm; Per-Åke Nygren; Mike Taussig; KTH; []
    Keywords : ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; ribosome display; phage display; combinatorial protein engineering; library; murine IgG1; SATB1; Ras; Raf; Genetic engineering including functional genomics; Genteknik inkl. funktionsgenomik; SRA - Molecular Bioscience; SRA - Molekylär biovetenskap;

    Abstract : Affinity proteins are invaluable tools in biotechnological and medical applications. This thesis is about combinatorial protein engineering principles for the generation of novel affinity proteins to purify mouse immunoglobulin, detect a potential cancer marker protein or inhibit a cell proliferation pathway. READ MORE

  7. 5. Affibody Molecules for PET Imaging

    Author : Joanna Strand; Tolmachev Vladimir; Sten Nilsson; Uppsala universitet; []
    Keywords : Affibody molecules; Molecular imaging; PET; Radiolabelling; HER2; PDGFRβ; Biomedical Radiation Science; Biomedicinsk strålningsvetenskap;

    Abstract : Optimization of Affibody molecules would allow for high contrast imaging of cancer associated surface receptors using molecular imaging. The primary aim of the thesis was to develop Affibody-based PET imaging agents to provide the highest possible sensitivity of RTK detection in vivo. READ MORE