Search for dissertations about: "affinitet"

Showing result 21 - 25 of 44 swedish dissertations containing the word affinitet.

2. 21. On the estimation of ligand binding affinities

   Author : Samuel Genheden; Beräkningskemi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; binding affinities protein-ligand complexes; host-guest complexes; MM GBSA; MM PBSA; LIE; PDLD s-LRA; alchemical methods; sampling; solvation; drug design;

   Abstract : A method to accurately estimate the binding affinity of a small molecule to a receptor would be indispensable in numerous fields. For instance, most drugs exert their action by binding to a macromolecule target. Thus, a lot of time and resources could be saved in drug design by predicting affinities by computer programs. READ MORE

4. 22. Treatment conditions for the removal of contaminants from road runoff

   Author : Magnus Hallberg; Gunno Renman; Jiri Marsalek; KTH; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; dissolved matter; filter bed; particulate matter; sedimentation; suspended solids; Environmental engineering; Miljöteknik;

   Abstract : The pollutant load in road runoff is related to traffic densities and road maintenance activities. Inurbanised areas treatment of road runoff is common and often considered necessary. The pollutantsare partitioned between the particulate and dissolved matter. However, the contaminantstend to have an affinity to the particulate material. READ MORE

5. 23. Progress of Weak Affinity Chromatography as a Tool in Drug Development

   Author : Elinor Meiby; Sten Ohlson; Manfred Raida; Linnéuniversitetet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; weak affinity chromatography; fragment based drug discovery; fragment screening; thrombin; trypsin; cyclin G-associated kinase; Hsp90; Pin1; cyclooxygenase; lipodisks; Biokemi; Biochemistry;

   Abstract : Weak Affinity Chromatography (WAC) is a technology that was developed to analyse weak (KD > 10-5 M) although selective interactions between biomolecules. The focus of this thesis was to develop this method for various applications in the drug development process.Fragment Based Drug Discovery is a new approach in finding new small molecular drugs. READ MORE

6. 24. Magnesium Chelatase: Insights into the first Step of Chlorophyll Biosynthesis

   Author : Nick Sirijovski; Biokemi och Strukturbiologi; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Electron microscopy; Proteobacteria; Mutants; Rhodobacter capsulatus; Tetrapyrrole; Plant biochemistry; Växtbiokemi; Biochemistry; Metabolism; Biokemi; metabolism; Proteins; enzymologi; enzymology; Proteiner; Chlorophyll biosynthesis; AAA proteins; Magnesium chelatase; Barley; ATPase;

   Abstract : The enzyme magnesium chelatase inserts magnesium into protoporphyrin IX (Proto) to produce to magnesium protoporphyrin IX, the first unique intermediate of the chlorophyll biosynthetic pathway. Magnesium chelatase is composed of three distinct proteins termed I (molecular weight ~40 kDa), D (~70 kDa) and H (~140 kDa). READ MORE

7. 25. C4b-binding protein: Identification of binding sites and a possible function of the interaction with protein S

   Author : Joanna Webb; Malmö Klinisk kemi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Clinical chemistry; apoptosis; binding sites; complement; C4b-binding protein; protein S; Klinisk kemi;

   Abstract : The subject of this thesis is plasma protein C4b-binding protein (C4BP). C4BP is an important regulator of the classical pathway of the complement system, a cascade-like system comprised of over 35 proteins, which partakes in the defence against micro-organisms and is involved of clearance of immune-complexes and apoptotic cells. READ MORE