Search for dissertations about: "affinity chromatography"
Showing result 11 - 15 of 127 swedish dissertations containing the words affinity chromatography.
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11. Superporous agarose a new material for chromatography
Abstract : Agarose, the most commonly employed chromatography base material in industrial purification processes for biomolecules – proteins, has almost ideal properties. The major disadvantage of the agarose support is its poor mechanical strength which excludes its use in high speed separations where small particles are needed in order to achieve improved chromatographic efficiency. READ MORE
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12. Progress of Weak Affinity Chromatography as a Tool in Drug Development
Abstract : Weak Affinity Chromatography (WAC) is a technology that was developed to analyse weak (KD > 10-5 M) although selective interactions between biomolecules. The focus of this thesis was to develop this method for various applications in the drug development process.Fragment Based Drug Discovery is a new approach in finding new small molecular drugs. READ MORE
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13. Primary Recovery of Biologically Active Compounds Using Macroporous Monolithic Hydrogels
Abstract : The completion of sequencing of human and other mammalian genomes opens a new era for drug development. New approaches have been proposed for tackling diseases such as development of small molecule therapies based on understanding of human genome and proteome, new proteinous based therapies, where the therapeutic protein can inhibit or modify a certain metabolic pathway or DNA-based therapies delivering a gene into the cell (e. READ MORE
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14. Selective Sorbents - Silica-immobilized affinity ligands and molecularly imprinted polymers
Abstract : The development of selective sorbents for the separation of various molecules, preferentially biomolecules, is described in this work. Affinity ligands were immobilized on small silica particles and used in high-performance liquid affinity chromatography (HPLAC). READ MORE
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15. Production and delivery of recombinant subunit vaccines
Abstract : Recombinant strategies are today dominating in thedevelopment of modern subunit vaccines. This thesis describesstrategies for the production and recovery of protein subunitimmunogens, and how genetic design of the expression vectorscan be used to adapt the immunogens for incorporation intoadjuvant systems. READ MORE