Search for dissertations about: "age related macular degeneration"

Showing result 21 - 25 of 32 swedish dissertations containing the words age related macular degeneration.

  2. 21. Scalable, safe and GMP-compatible production of embryonic stem cell derived retinal pigment epithelial cells

    Author : Sara Padrell Sánchez; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Regenerative medicine is an exponentially growing field that aims to regenerate a lost function, cell type or tissue due to damage, ageing or disease. Currently, more than 30,000 gene- and cell-based therapies have been or are being tested in clinical trials. READ MORE

  4. 22. Matrix metalloproteinases and their inhibitors in ocular neovascularization

    Author : Björn Steén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Angiogenesis; Neovascularization; Retina; Bruch membrane; Cornea; MMP; TIMP; VEGF; In situ hybridization.;

    Abstract : Growth of pathological new vessels (angiogenesis) in the eye is a leading cause of severe vision-loss. Ocular angiogenesis is seen in the anterior part of the eye as in corneal neovascularization, or in the posterior part as in diabetic retinopathy, retinopathy of prematurity or age-related macular degeneration. READ MORE

  5. 23. Investigation of potential prognostic and therapeutic genes in pathologic neovascularization of the retina

    Author : Parviz Mammadzada; Karolinska Institutet; Karolinska Institutet; Sweden Stockholm Karolinska Institutet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Pathologic angiogenesis of the retina is a hallmark of frequent blinding conditions among the elderly, such as proliferative diabetic retinopathy (PDR) and neovascular age-related macular degeneration (nAMD). The underlying mechanisms are complex. READ MORE

  6. 24. Mosaic loss of chromosome Y : methods for detection and consequences for affected leukocytes and men

    Author : Marcus Danielsson; Lars A. Forsberg; Ståhl Patrik; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mosaic loss of chromosome Y; mLOY; somatic mosaicism; Medicinsk genetik; Medical Genetics;

    Abstract : It has been known for centuries that men live shorter lives than women, but until recently, the biological mechanisms driving this sex bias has been poorly understood. Mosaic loss of chromosome Y (mLOY) refers to chromosome Y aneuploidy, a male specific and the most common somatic mutation in human blood cells. READ MORE

  7. 25. Mechanisms of malignant and non-malignant angiogenesis using zebrafish models

    Author : Lasse Dahl Ejby Jensen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Pathological angiogenesis significantly contribute to the onset, development and progression of most common and severe human diseases including cancer, metastatic disease, cardiovascular disease, age-related macular degeneration, diabetic retinopathy and retinopathy of prematurity. Under these pathological conditions, tissue hypoxia often acts as a trigger to switch on angiogenesis. READ MORE