Search for dissertations about: "age-related macular degeneration"

Showing result 11 - 15 of 31 swedish dissertations containing the words age-related macular degeneration.

  2. 11. Human embryonic stem cells for retinal repair : preclinical in vitro and in vivo studies for the treatment of age-related macular degeneration with human embryonic stem cell-derived retinal pigment epithelial cells

    Author : Sandra Petrus-Reurer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Age-related macular degeneration (AMD) is the major cause of vision loss in the industrialized countries in people above sixty years of age. The dry advanced form of the disease, also termed as geographic atrophy (GA), is characterized by the progressive death of retinal pigment epithelial cells (RPE) and consequent loss of the adjacent photoreceptor (PR) layer, leading to an impaired visual function. READ MORE

  4. 12. Uveal melanoma and macular degeneration : molecular biology and potential therapeutic applications

    Author : Mario A Economou; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Uveal melanoma; exudative AMD; IGF-1R; c-Met; prognostic markers; metastasis; oral treatment; VEGF;

    Abstract : Uveal melanoma is the most common primary intraocular malignant tumor in adults with 30% to 50% of patients that ultimately succumb to metastatic disease, mainly to the liver. Although new diagnostic and therapeutic tools have been developed during the most recent years, only the eye conservation rate has been achieved, while the survival rate remains poor. READ MORE

  5. 13. Localization of five human genes by clinical and molecular genetic methods

    Author : Mihailo Vujic; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Larsen syndrome; LRS1; Multiple hereditary exostoses; EXT2; Best macular dystrophy; VMD2; Noonan syndrome; NS3; Tripeptidyl peptidase-2; TPP2;

    Abstract : Four of the research projects reported in this thesis start from the gene effects observed in clinical practice. Finding a disease causing gene is challenging, exciting and beneficial for the patient, the family and for the society. READ MORE

  6. 14. Electrophysiology, Optical Coherence Tomography and Molecular Genetic Analysis in Patients with Glaucoma and/or Best Vitelliform Macular Dystrophy as Part of Clinical Care

    Author : Elisabeth Wittström; Lund Oftalmologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glaucoma; BVMD; BEST1; full-field ERG; mfERG; OCT;

    Abstract : Glaucoma is a common ophthalmic disease with multifactorial aetiology. There is growing evidence that glaucoma is a disease of the entire retina and not only the inner retina. READ MORE

  7. 15. Choroidal neovascularization (CNV) : clinical and experimental aspects

    Author : Lennart Berglin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CNV; angiogenesis; age-related macular degeneration; AMD; aging; surgery; endothelial cells; VEGF; MMP; TIMP; MMP-2; immunohistochemistry; ECM; RPE; Bruch s membrane; wound healing; inflammation; macrophages; in-situ hybridization; mRNA; immature vessels; MMP-9; TIMP- 3; MMP-2 deficiency;

    Abstract : This work comprises different aspects of choroidal neovacularization (CNV); a leading cause of visual loss in the aged. It is an example of angiogenesis and a complication of age-related macular degeneration (AMD) The purpose was to study if patient age influences outcome of CNV surgery, to characterize the cellular content of CNV, to analyze the expression of vascular endothelial growth factor (VEGF) and various matrix metalloproteinases (MMP) and their inhibitors (TIMP) in CNV and to study if MMP-2 influences experimental CNV growth. READ MORE