Search for dissertations about: "ah receptor"

Showing result 1 - 5 of 14 swedish dissertations containing the words ah receptor.

  2. 1. Bioassay analysis of dioxin-like compounds : response interactions and environmental transformation of Ah receptor agonists

    Author : Helena Olsman; Magnus Engwall; John P. Giesy; Örebro universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; bioassay; dioxin-like; Ah receptor; Biology; Biologi; Biology; Biologi;

    Abstract : Dioxin-like compounds mediate their toxicity by binding to the aryl hydrocarbon receptor (AhR) and through this receptor a cascade of biochemical and toxic events are triggered. Mechanism-specific dioxin bioassays utilise the AhR coupled induction of endogenous CYP1A proteins or reporter gene systems for detection of dioxin-like compounds and other AhR ligands. READ MORE

  4. 2. Syntehesis of potential ligands for the TCCDD (Ah) receptor : aiming at a better understanding of receptor structure and function

    Author : Joakim Tholander; KTH; []
    Keywords : ;

    Abstract : .... READ MORE

  5. 3. Gill EROD Activity in Fish : A Biomarker for Waterborne Ah-receptor Agonists

    Author : Alexandra Abrahamson; Ingvar Brandt; Björn Brunström; Janneche Utne Skaare; Uppsala universitet; []
    Keywords : Biology; biomarker; fish; gill; CYP1A; EROD; environmental monitoring; induction; inhibition; PAH; PCB; produced water; Biologi;

    Abstract : Induction of the cytochrome P450(CYP)1A protein and the connected increase in 7-ethoxyresorufin O-deethylase (EROD) activity are common biomarkers in fish. Enhanced activity of this protein signals exposure to Ah-receptor agonists such as chlorinated dioxins, co-planar polychlorinated biphenyls (PCBs) and certain polycyclic aromatic hydrocarbons (PAHs). READ MORE

  6. 4. Ah receptor mediated toxicity : studies in vitro and in a transgenic mouse model

    Author : Sara Brunnberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dioxin Ah Receptor; Arnt; TCDD; gene expression; reproductive tract; bone; heart;

    Abstract : The polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls are ubiquitously present in the environment. Humans are exposed mainly through diet to continuous low levels which on average are in close proximity to those considered tolerable. The foetus and newborn infant are considered as a particular risk group. READ MORE

  7. 5. Functional role of a constitutively active dioxin/Ah receptor in a transgenic mouse model

    Author : Patrik Andersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Dioxin Ah receptor; TCDD; dioxin; stomach tumor; osteopontin; peritoneal B1 B cells; transcription factor; gene expression;

    Abstract : The dioxin/ Aryl hydrocarbon receptor is a ligand-activated transcription factor that mediates most (if not all) of the toxic effects of the group of highly potent environmental pollutants collectively called dioxins and PCBs, including the highly toxic compound 2,3,7,8tetrachlorodibenzo-p-dioxin (TCDD). The toxic effects include immune suppression, endocrine disruption, impaired reproduction and carcinogenesis. READ MORE