Search for dissertations about: "aicd"

Showing result 1 - 5 of 12 swedish dissertations containing the word aicd.

  2. 1. Regulation of the pro-apoptotic protein Bim by T cell receptor triggering in human T cells

    Author : Elena Sandalova; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Bim; Apoptosis; Mitochondria; CTLs; AICD; TCR activation;

    Abstract : Bim is a significant pro-apoptotic member of Bcl-2 family of proteins; it is proved to be an important regulator of apoptosis: over the years it has been shown to play a pivotal role for the development and maintenance of homeostasis in many cellular systems and tissues. The Bcl-2 family of proteins is a group of key regulators of the mitochondrial, or intrinsic, pathway of apoptosis. READ MORE

  4. 2. Expression and function of the small immune adaptor protein SAP

    Author : Noemi Nagy; Karolinska Institutet; Karolinska Institutet; []
    Keywords : XLP; SAP; EBV; BL; lymphocytes; lymphoma; p53; apoptosis; AICD;

    Abstract : The Epstein-Barr virus (EBV) carrier state is widespread in humans. Primary infection can cause infectious mononucleosis (IM) that presents with variable clinical severity, but almost always subsides. For 50% of boys with a rare hereditary immunodeficiency, X-linked lymphoproliferative disease (XLP), primary infection with E13V has a fatal course. READ MORE

  5. 3. Regulation of non-responsiveness and death in cytotoxic T cells by the agonistic potency of MHC : peptide ligands

    Author : Michael Uhlin; Karolinska Institutet; Karolinska Institutet; []
    Keywords : CD8 T cells; APL; CTLs; non-responsiveness; AICD; lck; lipid rafts; partial agonism; TCR activation.;

    Abstract : CD8+ T lymphocytes are important for immunological control of infections and tumors. The key interaction required to initiate the process of T cell activation is the engagement of the T cell receptor (TCR) with a major histocompatibility complex (MHC) class I/peptide complex on an antigen presenting cell (APC). READ MORE

  6. 4. Studies on the gamma-secretase complex and processing of the Alzheimer's disease-associated amyloid precursor protein

    Author : Anna Bergman; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Alzheimer's disease (AD) is a devastating neurodegenerative disorder that causes the most common form of dementia. Pathological lesions, such as plaques consisting of the amyloid beta-peptide (Ab), are found in the brains of AD patients. Ab is produced by sequential cleavages of the amyloid precursor protein (APP) by beta- and gamma-secretase. READ MORE

  7. 5. Studies on gamma-secretase activity and products

    Author : Jenny Frånberg; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : gamma-Secretase is a transmembrane aspartyl protease involved in processing of a multitude of functionally diverse substrates within their transmembrane domains. gamma-Secretase cleavage of the amyloid precursor protein (APP) generates the APP intracellular domain (AICD) and the amyloid beta-peptide (Abeta). READ MORE