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Showing result 1 - 5 of 19 swedish dissertations matching the above criteria.

  2. 1. Platelets and airway remodeling : Mechanisms involved in platelet-induced fibroblast and airway smooth muscle cell proliferation in vitro

    Author : Ann-Charlotte B. Svensson Holm; Torbjörn Bengtsson; Eva Lindström; Mikael Adner; Linköpings universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : Airway remodeling is a contributing cause to the pathological structural changes, such as increased cell proliferation, observed in asthma. Platelets have been found in autopsy lungmaterial obtained from asthmatic patients and are well known to induce proliferation in vitro of a variety of cells. READ MORE

  4. 2. Characterization of fibroblast phenotypes in human airway remodeling

    Author : Kristoffer Larsen; Lungbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Medicin människa och djur ; remodeling; General biomedical sciences; Biomedicinska vetenskaper allmänt ; fibrocytes; proteoglycans; Asthma; fibroblasts;

    Abstract : Wound healing that precedes scar formation may be unbalanced under pathological conditions leading to structural changes of the tissue. At the moment, the mechanisms behind this unbalance are unclear. When these changes occur in internal organs such as the lung, they may result in organ dysfunction with fatal consequences for the patient. READ MORE

  5. 3. Remodeling of airway epithelium and lung extracellular matrix in COPD and IPF

    Author : Ulf Hedström; Lungbiologi; []
    Keywords : Chronic obstructive pulmonary disease; Idiopathic pulmonary fibrosis; Extracellular matrix; Epithelial cells; Remodeling;

    Abstract : .... READ MORE

  6. 4. Effects of Asthma Combination Therapy on Extracellular Matrix Remodeling in Human Lung Fibroblasts

    Author : Lizbet Todorova; Lungbiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Asthma; Proteoglycans; Lung fibroblasts; Collagen; Airway remodeling; TGFβ; Glucocorticoids; Combination therapy.; β2-agonist; MMPs;

    Abstract : Fibroblasts, being one of the resident and structural cells of the lung, have the capacity to produce inflammatory mediators, cytokines and extracellular matrix (ECM) proteins perpetuating the inflammation in the airways of asthmatics. Airway remodeling is also a prominent feature of asthma that affects the lung function causing a thickening of the airways. READ MORE

  7. 5. Remodeling of the pulmonary circulation - a novel response to allergic airway inflammation

    Author : Kristina Rydell-Törmänen; Luftvägsinflammation; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vascular remodeling; OVA; HDM; asthma;

    Abstract : Asthma is characterized, not only by inflammation but also by airway and vascular remodeling. Airway remodeling is established early in disease, structural alterations have been found in children, and is thought to contribute to asthma symptoms. Unfortunately, airway remodeling is considered difficult to reverse and it seldom resolves completely. READ MORE