Search for dissertations about: "albumin binding domain"

Showing result 26 - 30 of 35 swedish dissertations containing the words albumin binding domain.

  2. 26. Development of radiometal-based labelling techniques and tracers for non-invasive molecular imaging

    Author : Emma Jussing; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Metallic radionuclides, radiometals, have an important role in nuclear medicine. Their straightforward coordination radiochemistry allows for a large variety of applications. READ MORE

  4. 27. Engineering of alternative scaffold derived drug conjugates and fusion-toxins for targeted cancer therapy

    Author : Wen Yin; Torbjörn Gräslund; Serge Muyldermans; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; HER2; Affibody; Cancer; ADAPT; Protein engineering; PE38; DM1; MMAE; MMAF; Biotechnology; Bioteknologi;

    Abstract : Cancer is a major health problem, with premature death for many patients, and with a high monetary cost to society. The disease is complex to treat due to the many different types, but also because the disease-causing cells, that needs to be removed, are very similar to the normal cells. READ MORE

  5. 28. Tumor targeted delivery of cytotoxic payloads using affibody molecules and ABD-derived affinity proteins

    Author : Hao Liu; Torbjörn Gräslund; Stefan Ståhl; Nick Devoogdt; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Targeted tumor therapy; immunotoxins; ADCs; affibody molecule; ADAPT; pseudomonas exotoxin A; maytansinoid; Bioteknologi; Biotechnology;

    Abstract : Cancer treatment cost billions of dollars every year, but the mortality rate is still high. An ideal treatment is the so-called “magic bullets” that recognize and kill tumor cells while leaving normal cells untouched. READ MORE

  6. 29. Targeting Human Epidermal Growth Factor Receptors with Drug Conjugates Based on Affibody Molecules

    Author : Jie Zhang; Torbjörn Gräslund; Per-Åke Nygren; Marika Nestor; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Affibody molecule; HER2; HER3; affibody-drug conjugate; half-life; payload; Affibody-molekyl; HER2; HER3; affibody-läkemedelskonjugat; halveringstid; nyttolast; Biotechnology; Bioteknologi;

    Abstract : Cancer is a major public health challenge and the second leading cause of death in the world, with millions of new cases being diagnosed each year. Traditional cancer treatments such as surgery, radiation therapy, and chemotherapy are many times effective, but may also cause damage to healthy cells, leading to side effects. READ MORE

  7. 30. Generation and characterization of Affibody molecules targeting HER3

    Author : Magdalena Malm; Stefan Ståhl; Jennifer Cochran; KTH; []
    Keywords : Affibody molecules; epidermal growth factor receptors; HER3; ErbB3; combinatorial protein engineering; combinatorial library; staphylococcal surface display;

    Abstract : In the field of oncology, the ability to target specific tumor cells using highly selective targeting molecules is an attractive and emerging concept. In this context, the epidermal growth factor receptor HER3 has proven central to the biology behind many different human cancers and inhibition of the signaling mediated by this receptor could provide antitumoral effects. READ MORE