Search for dissertations about: "alcohol dependence"

Showing result 1 - 5 of 83 swedish dissertations containing the words alcohol dependence.

  1. 1. Reward-related genes and alcohol dependence

    Author : Sara Landgren; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alcohol; dependence; reward; smoking; body weight; gene; polymorphism; nAChR; ghrelin; GHS-R1A;

    Abstract : Introduction: The rewarding properties of alcohol are mediated by the brain reward systems, specifically by the cholinergic-dopaminergic reward link, involving both nicotinic acetylcholine receptors (nAChRs) as well as the ghrelin signalling system. The susceptibility for developing alcohol dependence is influenced by genetic factors. READ MORE

  2. 2. Preclinical investigations of GlyT-1 inhibition as a new concept for treatment of alcohol dependence

    Author : Helga Lidö Höifödt; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : Psykiatri experimentell ; Neurofarmakologi; alcohol; dependence; dopamine; GlyT-1 inhibition; nucleus accumbens; reward;

    Abstract : Alcohol addiction and abuse is a main contributor to the global burden of disease and is a high public health priority. Alcohol addiction is a chronically relapsing neurobiological disorder affecting multiple neurotransmitter systems. READ MORE

  3. 3. Studies on new pharmacological treatments for alcohol dependence - and the importance of objective markers of alcohol consumption

    Author : Andrea deBejczy; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : alcohol dependence; mirtazapine; varenicline; org 25935; alcohol markers; phosphatidylethanol; randomized controlled clinical trials RCT ; treatment; glycine transporter inhibitor; nAChR;

    Abstract : This thesis will guide you through three randomized controlled trials (RCT) on three pharmacotherapies for alcohol dependence; the antidepressant drug mirtazapine, the smoking cessation drug varenicline and the glycine-uptake inhibitor Org 25935. The mirtazapine study was an investigator initiated single-center harm-reduction study with alcohol consumption measured by self-report in a diary as main outcome. READ MORE

  4. 4. Serotonergic aspects on high consumption of alcohol in humans. Experimental and clinical studies

    Author : Matts Eriksson; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; alcohol; alcohol-dependence; serotonin; SSRI; MAO-B; DRD2 A1 A2 alleles; fenfluramine; mood;

    Abstract : In animal studies an association between alcohol intake and central serotonergic function has been demonstrated. There are also evidence for altered serotonergic neurotransmission in subgroups of alcohol-dependent subjects. READ MORE

  5. 5. Studies on alcohol habits : development and problems in a birth cohort of Swedish males

    Author : Peter Wennberg; Per-Anders Rydelius; Stockholms universitet; []
    Keywords : SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; Alcohol; alcoholism; continuity; classification; development; longitudinal; stability; psykologi; Psychology;

    Abstract : This work addresses several aspects of alcohol habits and problems in a male birth cohort. The studies focus on the prevalence of problematic alcohol use, different drinking patterns and the longitudinal development towards problematic alcohol use. READ MORE