Search for dissertations about: "alcohol dependence"
Showing result 1 - 5 of 92 swedish dissertations containing the words alcohol dependence.
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1. Reward-related genes and alcohol dependence
Abstract : Introduction: The rewarding properties of alcohol are mediated by the brain reward systems, specifically by the cholinergic-dopaminergic reward link, involving both nicotinic acetylcholine receptors (nAChRs) as well as the ghrelin signalling system. The susceptibility for developing alcohol dependence is influenced by genetic factors. READ MORE
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2. Preclinical investigations of GlyT-1 inhibition as a new concept for treatment of alcohol dependence
Abstract : Alcohol addiction and abuse is a main contributor to the global burden of disease and is a high public health priority. Alcohol addiction is a chronically relapsing neurobiological disorder affecting multiple neurotransmitter systems. READ MORE
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3. Studies on new pharmacological treatments for alcohol dependence - and the importance of objective markers of alcohol consumption
Abstract : This thesis will guide you through three randomized controlled trials (RCT) on three pharmacotherapies for alcohol dependence; the antidepressant drug mirtazapine, the smoking cessation drug varenicline and the glycine-uptake inhibitor Org 25935. The mirtazapine study was an investigator initiated single-center harm-reduction study with alcohol consumption measured by self-report in a diary as main outcome. READ MORE
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4. Serotonergic aspects on high consumption of alcohol in humans. Experimental and clinical studies
Abstract : In animal studies an association between alcohol intake and central serotonergic function has been demonstrated. There are also evidence for altered serotonergic neurotransmission in subgroups of alcohol-dependent subjects. READ MORE
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5. Studies on alcohol habits : development and problems in a birth cohort of Swedish males
Abstract : This work addresses several aspects of alcohol habits and problems in a male birth cohort. The studies focus on the prevalence of problematic alcohol use, different drinking patterns and the longitudinal development towards problematic alcohol use. READ MORE