Search for dissertations about: "alcohol dependence"

Showing result 16 - 20 of 92 swedish dissertations containing the words alcohol dependence.

  2. 16. Childhood bereavement, stress resilience, and cancer risk : an integrated register-based approach

    Author : Beatrice Kennedy; Katja Fall; Fang Fang; Unnur Valdimarsdottír; Scott Montgomery; Meena Kumari; Örebro universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alcohol; bereavement; cancer; drug use; epidemiology; health behaviour; psychological resilience; smoking; stress;

    Abstract : Accumulating evidence suggests that psychosocial stress and susceptibility to stressful exposures – stress resilience – influence the risk of various health outcomes, but the potential link with cancer occurrence is unclear. The aims of this thesis were to test if loss of a close relative, a marker of severe psychological stress, and stress resilience measured during late adolescence are associated with cancer risk later in life, as well as to explore potential underlying mechanisms. READ MORE

  4. 17. Endogenous Opioids and Voluntary Ethanol Drinking : Consequences of Postnatal Environmental Influences in Rats

    Author : Lisa Gustafsson; Ingrid Nylander; Erika Roman; Ryszard Przewlocki; Uppsala universitet; []
    Keywords : Pharmaceutical pharmacology; Maternal separation; Maternal deprivation; Handling; Isolation; Alcohol; Two-bottle model; Four-bottle model; MEAP; Dynorphin B; Nociceptin orphanin FQ; Radioimmunoassay; Farmaceutisk farmakologi;

    Abstract : Genetic and environmental factors interact to determine the individual vulnerability to develop ethanol dependence. The neurobiological mechanisms underlying these processes are not fully understood. Endogenous opioid peptides have been suggested to contribute. READ MORE

  5. 18. Maternal Separation in Rats : An Experimental Model for Long-Term Effects of Early Life Experiences on Neurochemistry, Voluntary Ethanol Intake and Exploration and Risk Assessment Behavior

    Author : Erika Roman; Ingrid Nylander; J. Dee Higley; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical pharmacology; Handling; Maternal Deprivation; Environment; Opioids; Dopamine; Alcohol; Stress; Concentric Square Field; Open Field; Elevated Plus-maze; Farmaceutisk farmakologi; Pharmaceutical pharmacology; Farmaceutisk farmakologi;

    Abstract : The period of early life is important for the development of individual brain function and behavior. Human studies have shown altered vulnerability to develop psychopathology and/or excessive drug intake, possibly leading to dependence, as a consequence of early life experiences. READ MORE

  6. 19. Molecular Adaptations in the Endogenous Opioid System in Human and Rodent Brain

    Author : Muhammad Zubair Hussain; Georgy Bakalkin; Anita Hansson; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endogenous Opioid System; Dynorphins; Lateralization; Alcohol Dependence; Emotions; Traumatic Brain Injury; Anterior Cingulate Cortex; Dorsal Striatum; Neuroscience; Neurovetenskap;

    Abstract : The aims of the thesis were to examine i) whether the endogenous opioid system (EOS) is lateralized in human brain areas involved in processing of emotions and pain; ii) whether EOS responses to unilateral brain injury depend on side of lesion, and iii) whether in human alcoholics, this system is involved in molecular adaptations in brain areas relevant for cognitive control of addictive behavior and habit formation.The main findings were that (1) opioid peptides but not opioid receptors and classic neurotransmitters are markedly lateralized in the anterior cingulate cortex involved in processing of  positive and negative emotions and affective component of pain. READ MORE

  7. 20. Epigenetic Dysregulations in the Brain of Human Alcoholics : Analysis of Opioid Genes

    Author : Igor Bazov; Georgy Bakalkin; Catharina Lavebratt; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; neuropeptides; dynorphin; human brain; alcohol dependence; epigenetics; gene transcription;

    Abstract : Neuropeptides are special in their expression profiles restricted to neuronal subpopulations and low tissue mRNA levels. Genetic, epigenetic and transcriptional mechanisms that define spatiotemporal expression of the neuropeptide genes have utmost importance for the formation and functions of neural circuits in normal and pathological human brain. READ MORE