Search for dissertations about: "alcoholic liver diseases"

Showing result 1 - 5 of 15 swedish dissertations containing the words alcoholic liver diseases.

2. 1. Studies on alcoholic liver disease

   Author : Knut Stokkeland; Karolinska Institutet; Karolinska Institutet; []
   Keywords : alcohol cirrhosis; cytochromes; autoantibodies; mortality; morbidity; prognosis; epidemiology; esophageal varices; lifetime drinking; lifetime alcohol intake;

   Abstract : The overall aim of this thesis was to explore the impact of alcoholic cirrhosis in Sweden, and the relation between drinking patterns and beverage types and alcoholic cirrhosis, and to evaluate the possible role of autoantibodies in the pathogenesis of alcohol related liver disease. We found that rats had appearance of IgG against rat CYP3A 1 and CYP2E 1 during chronic ethanol feeding We found that patients had reactivity against CYP3A4 and CYP2E I in about 20 to 30% and 10 to 20% of the alcoholic sera. READ MORE

4. 2. Liver cirrhosis-epidemiological and Clinical Aspects

   Author : Steingerður Anna Gunnarsdóttir; Göteborgs universitet; []
   Keywords : Liver cirrhosis; etiology; alcoholic liver disease; mortality; portal hypertension; esophageal varices; variceal bleeding; hepatitis C; hepatocellular cancer; malignancies; small intestinal motility; small intestinal bacterial overgrowth;

   Abstract : Liver cirrhosis is the end-stage of many different chronic liver diseases. Limited data exists on the epidemiology, natural history and complications of liver cirrhosis such as esophageal varices and malignancies in the Nordic countries after the discovery of hepatitis C (HCV). READ MORE

5. 3. Non-alcoholic fatty liver disease : an emerging liver disease

   Author : Cecilia Söderberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The aim of the study was to evaluate what NAFLD is from a molecular perspective, what influences the disease progression and what the prognosis of the disease is. Fatty liver has earlier often been associated with excessive alcohol intake and only in the last two decades has it been viewed as a condition in non- drinkers i.e. READ MORE

6. 4. Microbial modulation of metabolic diseases

   Author : Antonio Molinaro; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Microbiota; Glucose Metabolism; type 2 diabetes; NAFLD; non-alcoholic fatty liver disease;

   Abstract : The gut microbiota, the ensemble of microorganisms living in the gastrointestinal tract, and the host have a mutualist relationship. Alterations of this delicate equilibrium can lead to changes in microbiota composition and/or function leading to the onset of metabolic diseases (e.g., type 2 diabetes and non-alcoholic fatty liver diseases). READ MORE

7. 5. Importance of iron overload and steatosis in patients with chronic liver disease

   Author : Joel Marmur; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : This thesis deals with the importance of hepatic iron and fat deposition in the context of chronicliver disease, with special focus on the role of the S65C mutation in the hemochromatosis cryptogenic cirrhosis (CC) in patients evaluated for liver transplantation, the expressions of innate and adaptive immunity in non-alcoholic steatohepatitis (NASH), and the role of the ironregulatory hormone hepcidin in dysmetabolic iron overload (DIO). NAFLD is the most common liver disease in the Western world. READ MORE