Search for dissertations about: "alf kastbom"
Showing result 1 - 5 of 6 swedish dissertations containing the words alf kastbom.
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1. Autoantibodies and genetic variation in rheumatoid arthritis : aspects on susceptibility and disease course
Abstract : Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and subsequent destruction of synovial joints. Although its causes remain largely unknown, a substantial genetic contribution is known to exist. READ MORE
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2. Systemic and local regulation of experimental arthritis by IFN-α, dendritic cells and uridine
Abstract : In this thesis, we have studied the immunological processes of joint inflammation that may be targets for future treatment of patients with arthritis. We focus on the immune-modulating properties of interferon-α (IFN-α) and uridine in experimental arthritis. READ MORE
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3. Fc receptors and immunoglobulins in polyarthritis : A matter of function, supply and demand?
Abstract : Fc receptors (FcR) and immunoglobulins (Ig) play important roles in the defence against pathogens. However, altered interactions of these may promote chronic inflammation in rheumatic diseases. An excess of Igs forming immune complexes (IC) could lead to continuous FcR activation and spreading of autoimmune inflammation to other tissues. READ MORE
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4. Secretory Autoantibodies in Rheumatoid Arthritis
Abstract : Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease in which autoantibodies, such as anti-citrullinated protein antibodies (ACPA), can be detected in the serum of patients. Autoantibodies may appear in the circulation years before clinical signs of joint inflammation occur, indicating that early immunological pathogenetic steps take place outside of the joints. READ MORE
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5. Circulating and Mucosal Antibodies to Citrullinated Antigens in Rheumatoid Arthritis
Abstract : Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation and subsequent destruction of cartilage and bone. The etiology is largely unknown, although genetic as well as environmental factors are involved. The manifestations and consequences of RA differ between individuals. READ MORE