Search for dissertations about: "allelic exclusion"

Found 5 swedish dissertations containing the words allelic exclusion.

  2. 1. Regulation of B cell development by antigen receptors

    Author : Jannek Hauser; Thomas Grundström; Yuan Zhuang; Umeå universitet; []
    Keywords : calcium; calmodulin; e-proteins; E2A; B cell development; antigen receptor signaling; surrogate light chains; RAG; allelic exclusion; V D J recombination; AID; negative feedback regulation; plasma cell differentiation;

    Abstract : The developmental processes of lymphopoiesis generate mature B lymphocytes from hematopoietic stem cells through increasingly restricted intermediates. Networks of transcription factors regulate these cell fate choices and are composed of both ubiquitously expressed and B lineage-specific factors. READ MORE

  4. 2. T cells in Autoimmunity: studies on murine type II collagen-induced arthritis

    Author : Alexandre Corthay; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; Autoimmunity T lymphocytes collagen-induced arthritis Glycosylation TCR; transplantation; serology; Immunology; serologi; Skeleton; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi;

    Abstract : Collagen-induced arthritis (CIA) is a mouse model for rheumatoid arthritis, in which autoimmunity is induced by immunization with type II collagen (CII), a cartilage-specific protein. In the present work, alpha/beta T cells were shown to be required for CIA and for the production of anti-CII IgG antibodies, whereas gamma/delta T cells were neither necessary nor sufficient for development of CIA. READ MORE

  5. 3. B lymphocytes in solid human malignancies

    Author : Ali Zirakzadeh; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cancer remains one of the leading causes of death worldwide. Modern treatments such as immunotherapy and neoadjuvant chemotherapy exhibit promising results. However better understanding of the treatments may lead to optimizations and consequently better prognosis. READ MORE

  6. 4. Juvenile myoclonic epilepsy : clinical, genetic, clinical pharmacological, and neurophysiological studies

    Author : Anders Sundqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : epilepsy; juvenile myoclonic epilepsy; idiopathic generalised epilepsy; differential diagnosis; genetics; linkage; valproic acid; pharmacokinetics; treatment; drug monitoring; EEG; neurophysiology; neuropsychology. Printed in Sweden by Repro Print; ;

    Abstract : Juvenile myoclonic epilepsy (JME) has been considered to be a discrete phenotype. Evidence from segregation analysis and twin studies suggest that JME is a genetically determined disease, and two previous linkage studies of separately ascertained kindreds have suggested that a JME locus, EJM 1, resides on chromosome 6p close to the HLA region. READ MORE

  7. 5. Variant antigens at the infected red cell surface in Plasmodium falciparum malaria

    Author : Victor Fernandez; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Plasmodium falciparum; blood stages; variant antigens; var PfEMP1; rif RIFIN; adhesive phenotypes; cytoadherence; endothelial receptor; PECAM-1 CD31; rosetting; heparan sulphate;

    Abstract : Disease severity in Plasmodium falciparum infections is, to a large extent, a consequence of the parasite's efficient escape from die human host defences. Sequestration and antigenic variation are two evasion mechanisms featured by P.falciparum. READ MORE