Search for dissertations about: "allopregnanolone"

Showing result 1 - 5 of 18 swedish dissertations containing the word allopregnanolone.

  1. 1. Allopregnanolone and mood studies of postmenopausal women during treatment with progesterone

    University dissertation from Umeå : Klinisk vetenskap

    Author : Lotta Andréen; Torbjörn Bäckström; Viveca Odlind; [2006]
    Keywords : Obstetrics and gynaecology; Progesterone; Allopregnanolone; GABA; mood; bimodal; Obstetrik och kvinnosjukdomar;

    Abstract : Introduction. Allopregnanolone and pregnanolone (neuroactive metabolites of progesterone) act as positive modulators of the GABAA receptor system which is the major inhibitory system in CNS. Contradictory results on the effect of GABAA receptor modulators are reported. READ MORE

  2. 2. Allopregnanolone effects in women clinical studies in relation to the menstrual cycle, premenstrual dysphoric disorder and oral contraceptive use

    University dissertation from Umeå : Umeå University

    Author : Erika Timby; Marie Bixo; Torbjörn Bäckström; Anna-Carin N Wihlbäck; C Neill Epperson; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; GABAA receptor; menstrual cycle; premenstrual dysphoric disorder; saccadic eye velocity; oral contraceptives; hypothalamic amenorrhea;

    Abstract : Background: Premenstrual dysphoric disorder (PMDD) affects 3–8% of women in fertile ages. Combined oral contraceptives (OCs) are widely used and some users experience adverse mood effects. The cyclicity of PMDD symptoms coincides with increased endogenous levels of allopregnanolone after ovulation. READ MORE

  3. 3. Tolerance and antagonism to allopregnanolone effects in the rat CNS

    University dissertation from Umeå : Klinisk vetenskap

    Author : Sahruh Turkmen; Inga-Maj Johansson; Agneta Nordberg; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; GABA-A receptor; UC1011; Spatial memory; Morris Water Maze; Tolerance; Silent second; mRNA; MEDICINE Surgery Obstetrics and women s diseases Obstetrics and gynaecology; MEDICIN Kirurgi Obstetrik och kvinnosjukdomar Obstetrik och gynekologi;

    Abstract : Many studies have suggested a relationship between sex steroids and negative mental and mood changes in women. Allopregnanolone, a potent endogenous ligand of the GABA-A receptor and a metabolite of progesterone, is one of the most accused neuroactive steroids. READ MORE

  4. 4. Stress steroids as accelerators of Alzheimer's disease. Effects of chronically elevated levels of allopregnanolone in transgenic AD models

    University dissertation from Umeå : Umeå universitet

    Author : Sara Bengtsson; Mingde Wang; Torbjörn Bäckström; Maja Johansson; Caroline Graff; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; Alzheimer s disease; beta-amyloid; synaptophysin; chronic stress; Morris water maze; obstetrik och gynekologi; Obstetrics and Gynaecology; medicinsk farmakologi; Medical Pharmacology; Neurology; neurologi; Geriatrics; geriatrik; medical behavioral science; medicinsk beteendevetenskap;

    Abstract : Background Alzheimer’s disease (AD) and dementia are devastating con­ditions not only for the affected patients but also for their families.  The economical costs for the society are tremendous. READ MORE

  5. 5. GABA-steroid effects in healthy subjects and women with polycystic ovary syndrome

    University dissertation from Umeå : Umeå University

    Author : Helena Hedström; Torbjörn Bäckström; Marie Bixo; Ian Milsom; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; isoallopregnanolone; gonadotropins; GABA-A receptor; women; polycystic ovary syndrome; saccade; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Background: The progesterone metabolite allopregnanolone is involved in several clinical conditions in women, e.g. premenstrual dysphoric disorder. It is a very potent GABA-steroid with GABA-A receptor effects similar to other GABA-agonists, e. READ MORE