Search for dissertations about: "allopregnanolone"

Showing result 1 - 5 of 20 swedish dissertations containing the word allopregnanolone.

  1. 1. Allopregnanolone and mood studies of postmenopausal women during treatment with progesterone

    University dissertation from Umeå : Klinisk vetenskap

    Author : Lotta Andréen; Umeå universitet.; [2006]
    Keywords : Obstetrics and gynaecology; Progesterone; Allopregnanolone; GABA; mood; bimodal; Obstetrik och kvinnosjukdomar;

    Abstract : Introduction. Allopregnanolone and pregnanolone (neuroactive metabolites of progesterone) act as positive modulators of the GABAA receptor system which is the major inhibitory system in CNS. Contradictory results on the effect of GABAA receptor modulators are reported. READ MORE

  2. 2. Allopregnanolone effects in women clinical studies in relation to the menstrual cycle, premenstrual dysphoric disorder and oral contraceptive use

    University dissertation from Umeå : Umeå University

    Author : Erika Timby; Umeå universitet.; [2011]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; GABAA receptor; menstrual cycle; premenstrual dysphoric disorder; saccadic eye velocity; oral contraceptives; hypothalamic amenorrhea;

    Abstract : Background: Premenstrual dysphoric disorder (PMDD) affects 3–8% of women in fertile ages. Combined oral contraceptives (OCs) are widely used and some users experience adverse mood effects. The cyclicity of PMDD symptoms coincides with increased endogenous levels of allopregnanolone after ovulation. READ MORE

  3. 3. Allopregnanolone effects on food intake and weight gain

    University dissertation from Umeå : Umeå universitet

    Author : Ellinor Holmberg; Umeå universitet.; [2015]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allopregnanolone; neurosteroid; GABA; GABAA receptor; food intake; weight gain; obesity; hyperphagia; diurnal rhythm; schedule feeding; high fat diet; electrophysiology; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Abstract : Background Obesity is currently one of the major causes of ill health and it is clear that overeatingis the cause of obesity. However, the actions of many endogenous factors that contribute to overeating are still not well understood. READ MORE

  4. 4. Tolerance and antagonism to allopregnanolone effects in the rat CNS

    University dissertation from Umeå : Klinisk vetenskap

    Author : Sahruh Turkmen; Umeå universitet.; [2006]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; GABA-A receptor; UC1011; Spatial memory; Morris Water Maze; Tolerance; Silent second; mRNA; MEDICINE Surgery Obstetrics and women s diseases Obstetrics and gynaecology; MEDICIN Kirurgi Obstetrik och kvinnosjukdomar Obstetrik och gynekologi;

    Abstract : Many studies have suggested a relationship between sex steroids and negative mental and mood changes in women. Allopregnanolone, a potent endogenous ligand of the GABA-A receptor and a metabolite of progesterone, is one of the most accused neuroactive steroids. READ MORE

  5. 5. Stress steroids as accelerators of Alzheimer's disease. Effects of chronically elevated levels of allopregnanolone in transgenic AD models

    University dissertation from Umeå : Umeå universitet

    Author : Sara Bengtsson; Umeå universitet.; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allopregnanolone; Alzheimer s disease; beta-amyloid; synaptophysin; chronic stress; Morris water maze; obstetrik och gynekologi; Obstetrics and Gynaecology; medicinsk farmakologi; Medical Pharmacology; neurologi; Neurology; geriatrik; Geriatrics; medicinsk beteendevetenskap; medicinsk beteendevetenskap;

    Abstract : Background Alzheimer’s disease (AD) and dementia are devastating con­ditions not only for the affected patients but also for their families.  The economical costs for the society are tremendous. READ MORE