Search for dissertations about: "allylic substitution"

Showing result 11 - 15 of 21 swedish dissertations containing the words allylic substitution.

  2. 11. Copper- and nickel-catalyzed cross-coupling reactions : synthesis of 2-substituted 1,3-dienes and mechanistic and synthetic studies of the copper-mediated allylic substitution reaction

    Author : A. Sofia E. Karlström; Alexandre Alexakis; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic Chemistry; organisk kemi;

    Abstract : .... READ MORE

  4. 12. Methods for Asymmetric Olefination Reactions; Development and Application to Natural Product Synthesis

    Author : Daniel Strand; Tobias Rein; Viresh Rawal; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Antitumor agents; Asymmetric Horner-Wadsworth-Emmons; Desymmetrization; Metal-catalyzed olefination; Mucocin; Palladium-catalyzed allylic substitution; Parallel kinetic resolution; Pyranicin; Pyragonicin; Rhenium; Stereoconvergent synthesis; Stereodivergent synthesis; Stereoselective synthesis; Tetrahydropyran; Wittig reaction; Organic chemistry; Organisk kemi;

    Abstract : This thesis deals with the development and application of methods for asymmetric olefinations, in particular Horner-Wadsworth-Emmons (HWE) reactions, in the synthesis of certain natural products. Relying on asymmetric HWE reactions to access key building blocks, two natu-ral products, pyranicin and pyragonicin, were synthesized from common late intermediates. READ MORE

  5. 13. Transition Metal- and Enzyme-Catalyzed Reactions of Primary Amines and Allylic Alcohols : Powerful Tools in the Preparation of Pharmaceutically Important Compounds

    Author : Lisa K. Thalén; Jan-Erling Bäckvall; Dirk De Vos; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Dynamic kinetic resolution; racemization; catalysis; hydrogen transfer; kinetic resolution; norsertraline; alpha-methyl carboxylic acids; pipecoloxylidide; organisk kemi; Organic Chemistry;

    Abstract : Dynamic kinetic resolution (DKR) has been applied to primary amines utilizing a ruthenium catalyst and an (R)-selective lipase to provide the corresponding amides in up to 95% isolated yield and up to >99% ee. Further investigations of the chemoenzymatic DKR of amines show that it is general and can be applied to a wide range of amines. READ MORE

  6. 14. Employment of Palladium Pincer Complex Catalysts and Lewis Acids for Synthesis and Transformation of Organometallic Compounds

    Author : Johan Kjellgren; Kálmán J. Szabó; Gerard van Koten; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi;

    Abstract : This thesis is mainly focused on the development of new palladium catalyzed transformations using so-called “pincer” complexes. These complexes were applied as catalysts in two important areas of organometallic chemistry: substitution of propargylic substrates by dimetallic reagents; and allylation of aldehydes and imines by allylstannanes. READ MORE

  7. 15. Enantio- and Regioselective Iridium-Catalyzed Hydrogenation of Olefins : From Development to Total Synthesis

    Author : Cristiana Margarita; Pher Andersson; Xavier Verdaguer; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Asymmetric hydrogenation; Iridium; Regioselectivity; Kinetic resolution; Total synthesis; organisk kemi; Organic Chemistry;

    Abstract : The work presented in this thesis concerns the iridium-catalyzed asymmetric hydrogenation of cyclic olefins and allylic alcohols for the preparation of useful chiral intermediates with various substitution patterns. The strategy provides stereocontrol for both non-functionalized as well as functionalized substrates and aims to be implemented in the stereoselective preparation of chiral building blocks having more than one stereocenter. READ MORE