Search for dissertations about: "alpha 1 -Antitrypsin"

Showing result 1 - 5 of 770 swedish dissertations containing the words alpha 1 -Antitrypsin.

2. 1. Notch Signaling in Human Neuroblastoma Cells

   Author : Marie Stockhausen; Institutionen för translationell medicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Hes-1; Medicin människa och djur ; Medicine human and vertebrates ; hypoxia; TGF-alpha; EGFR; ERK1 2; Ras MAPK; differentiation; valproic acid; ubiquilin-1; neuroblastoma; Hash-1; Cytologi; onkologi; cancer; cancerology; Cytology; Notch;

   Abstract : Neuroblastoma is a childhood tumor derived from the sympathetic nervous system (SNS). It is believed that the tumors arise from cells halted in their differentiation and due to their immature phenotype; they express proteins normally only detected during embryogenesis. One such protein is Hash-1, which is required for formation of the SNS. READ MORE

4. 2. Hypoxia inducible factor 1 alpha : dependent and independent regulation of hematopoietic stem cells and leukemia

   Author : Camilla Halvarsson; Jan-Ingvar Jönsson; Mikael Sigvardsson; Kamil Kranc; Linköpings universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : This thesis has studied the role of low oxygen levels, or hypoxia, in hematopoietic stem cells (HSCs) and how, at the molecular level, it regulates stem cell maintenance and protects against oxidative stress induced by reactive oxygen species (ROS). HSCs reside within the bone marrow in specific niches created by a unique vascularized environment, which is suggested to be hypoxic and crucial for HSCs by maintaining a quiescent state of cell cycle and by redirecting metabolism away from the mitochondria to glycolysis. READ MORE

5. 3. Alpha-1-microglobulin, heme-binding protein, reductase and antioxidant

   Author : Maria Allhorn; Infektionsmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reduction; inflammation; chronic ulcers; collagen; low density lipoproteins; Medicin människa och djur ; Medicine human and vertebrates ; antioxidation; heme; hemoglobin; alpha-1-microglobulin; lipocalin;

   Abstract : This thesis describes structural and functional studies of alpha-1-microglobulin (a1m), a 26 kDa plasma and tissue protein that is evolutionarily well-conserved and belongs to the lipocalin superfamily. The lipocalins are polypeptides of 160-190-amino acids that are folded into an 8-stranded beta-barrel forming a pocket with a hydrophobic interior. READ MORE

6. 4. Alpha-1-microglobulin: Innate defence against pathological oxidation

   Author : Magnus Gram; Infektionsmedicin; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha-1-microglobulin; pathological oxidation; hemoglobin; heme; radiation; oxidation; ROS; hemoglobin and heme antagonist; radical scavenger;

   Abstract : Oxidative stress has been implicated as an important factor in the progression of many diseases. An imbalance in the redox-system may cause oxidation of cells and molecules, which might subsequently lead to tissue damage. READ MORE

7. 5. Structure and distribution of alpha-1-microglobulin proteins

   Author : Tord Berggård; Institutionen för experimentell medicinsk vetenskap; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteins; lysine; chromophore; placenta; immunohistochemistry; albumin; prothrombin; plasma; bikunin; lipocalin; alpha-1-microglobulin; protein HC; enzymology; Proteiner; enzymologi;

   Abstract : This thesis describes studies of the structure and tissue distribution of alpha-1-microglobulin (a1-m), a member of the lipocalin protein superfamily with immunosuppressive properies. It was shown that a1-m appears in human plasma in five major forms. READ MORE