Search for dissertations about: "alpha 1-antitrypsin"
Showing result 1 - 5 of 22 swedish dissertations containing the words alpha 1-antitrypsin.
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1. Severe and moderate alpha-1-antitrypsin deficiency at the age of 30
Abstract : Alpha-1-antitrypsin (AAT) is a glycoprotein synthesised in the liver. Its main role is to protect lung tissue from destruction by neutrophil elastase. In severe (PiZZ) AAT deficiency, there is an increased risk of emphysema, especially in smokers. READ MORE
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2. Clinical course and prognosis of individuals with severe alpha 1-antitrypsin deficiency (PiZZ)
Abstract : Severe alpha-1 antitrypsin deficiency (AATD) is a genetic disorder associated with increases risk of developing of chronic obstructive lung disease and liver disease. The Swedish National Registry for individuals with severe AATD was started 1991.Up to October 2008, a total of 1349 individuals were included in the registry. READ MORE
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3. Alpha-1-antitrypsin deficiency (PiZ): Clinical studies with special regard to hepatic and vasculitic disorders
Abstract : Homozygous alpha-1-antitrypsin (AAT)deficiency (PiZZ) is known to predispose to emphysema and chronic liver disease (CLD). The overall aim of the studies upon which this thesis is based was to investigate extra-pulmonary disease manifestations of AAT deficiency with special reference to hepatic and vasculitic disorders. READ MORE
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4. Alpha 1-antitrypsin: A Role in Cancer Progression
Abstract : Alpha1-antitrypsin (AAT), a circulating single-chain glycoprotein is the most abundant serine proteinase inhibitor in human plasma. AAT is an acute phase protein, its levels increase rapidly to concentrations exceeding 50mM in response to inflammation, infection and malignant diseases. READ MORE
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5. Chronic Obstructive Pulmonary Disease: Role of Alpha-1-antitrypsin
Abstract : The only proven genetic risk factor for Chronic Obstructive Pulmonary Disease (COPD) is an inherited Z (Glu342¡úLys) deficiency of alpha-1-antitrypsin (AAT), a major inhibitor of neutrophil elastase. In vivo, AAT is found in both native (inhibitory) and modified (non-inhibitory) forms. READ MORE