Search for dissertations about: "alpha 7 nicotinic acetylcholine receptor"

Found 5 swedish dissertations containing the words alpha 7 nicotinic acetylcholine receptor.

  2. 1. The role of the alpha 7 nicotinic acetylcholine receptor in inflammation and brain injury

    Author : Maria Hammarlund; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha 7 nicotinic acetylcholine receptor; inflammation; brain injury; CHRNA7; CHRFAM7A; stroke; hypoxia ischemia; neonatal encephalopathy; human; PBMC;

    Abstract : The alpha 7 nicotinic acetylcholine receptors (α7nAChR) are expressed in the nervous system as well as on peripheral immune cells where it participates in the cholinergic anti-inflammatory pathway. Inflammation is a common component in the pathology of many diseases and injuries, including brain damage. READ MORE

  4. 2. Neuronal nicotinic receptor subtypes in normal ageing, Alzheimer's disease and schizophrenia : influences of neuropathological mechanisms as studied in human autopsy brain and transgenic mice

    Author : Amelia Marutle; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Ageing; Alzheimer s disease; P-amyloid; Nicotinic acetylcholine receptor subtypes; Postmortem human brain; Schizophrenia; Transgenic mice;

    Abstract : Neuronal nicotinic acetylcholine receptors (nAChRs) are transmitter-gated ion channel receptors which are widely distributed in the brain. They mediate the effects of several neurotransmitters including ACh, DA, 5-HT and NA and are important for many normal physiological functions in the brain and are also implicated in a number of CNS disorders, such as AD, PD, schizophrenia, Tourette's syndrome and familial epilepsy. READ MORE

  5. 3. Nicotinic effects on midbrain dopamine neurons : a dual mechanism of action

    Author : Björn Schilström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : nicotine; dopamine; ventral tegmental area; glutamate; microdialysis; Fos expression; NMDA receptor; presynaptic;

    Abstract : The neurons of the mesocorticolimbic dopamine system are located in the ventral tegmental area (VTA) in the mesencephalon and send their projections to forebrain structures, such as the prefrontal cortex, the amygdala and the nucleus accumbens. The dopamine system is important in regulating mood and motivation as well as cognitive function and appear to be primarily involved in drug dependence, since most drugs abused by man stimulate this system. READ MORE

  6. 4. Understanding inflammation requires neuroscience

    Author : Alessandro Gallina; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Inflammation and its resolution are processes subject to neural regulation (1). The best-characterized immune-regulating reflex is the “inflammatory reflex”, in which the efferent branch of the vagus nerve plays a central role in regulating cytokine-release in the periphery. READ MORE

  7. 5. Fluorescence correlation spectroscopy, photophysical aspects and applications

    Author : Jerker Widengren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Fluorescence correlation spectroscopy (FCS) is a technique where dynamic processes on the molecular level are studied by the use of fluorescence. The molecules are excited within a focused stationary laser beam and the resulting fluorescence fluctuations are analyzed in the form of an autocorrelation function. READ MORE