Search for dissertations about: "alpha-1-antitrypsin"

Showing result 1 - 5 of 23 swedish dissertations containing the word alpha-1-antitrypsin.

  2. 1. Severe and moderate alpha-1-antitrypsin deficiency at the age of 30

    Author : Elisabeth Bernspång; allergologi och palliativ medicin Lungmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cohort; screening; alpha-1-antitrypsin; lung function; CT densitometry; liver;

    Abstract : Alpha-1-antitrypsin (AAT) is a glycoprotein synthesised in the liver. Its main role is to protect lung tissue from destruction by neutrophil elastase. In severe (PiZZ) AAT deficiency, there is an increased risk of emphysema, especially in smokers. READ MORE

  4. 2. Clinical course and prognosis of individuals with severe alpha 1-antitrypsin deficiency (PiZZ)

    Author : Hanan Tanash; allergologi och palliativ medicin Lungmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lung transplantation; occupation exposure; siblings; smoking; standardized mortality ratio; survival.; causes of death; alpha-1-antitrypsin deficiency;

    Abstract : Severe alpha-1 antitrypsin deficiency (AATD) is a genetic disorder associated with increases risk of developing of chronic obstructive lung disease and liver disease. The Swedish National Registry for individuals with severe AATD was started 1991.Up to October 2008, a total of 1349 individuals were included in the registry. READ MORE

  5. 3. The Clinical Course of Severe Alpha-1-Antitrypsin Deficiency: Registry-Based National Studies

    Author : Adriana-Maria Hiller; Internmedicin - epidemiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alpha-1-antitrypsin deficiency; Lung function; Natural course; Registry; screening;

    Abstract : .... READ MORE

  6. 4. Alpha 1-antitrypsin: A Role in Cancer Progression

    Author : Inga Zelvyté; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; onkologi; Cytologi; cancerology; oncology; Cytology; invasion; neutrophils; cancer cell; Alpha1- antitrypsin; proteinase inhibitors;

    Abstract : Alpha1-antitrypsin (AAT), a circulating single-chain glycoprotein is the most abundant serine proteinase inhibitor in human plasma. AAT is an acute phase protein, its levels increase rapidly to concentrations exceeding 50mM in response to inflammation, infection and malignant diseases. READ MORE

  7. 5. Alpha-1-antitrypsin deficiency (PiZ): Clinical studies with special regard to hepatic and vasculitic disorders

    Author : Abdul-Nasser Elzouki; Malmö Institutionen för kliniska vetenskaper; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastro-enterology; systemic vasculitis; small-vessel vasculitis; serpins; genetic hemochromatosis; chronic hepatitis C; chronic liver disease; Alpha-1-antitrypsin deficiency; alpha-1-antichymotrypsin deficiency; Gastroenterologi; Urology; nephrology; Urologi; nefrologi;

    Abstract : Homozygous alpha-1-antitrypsin (AAT)deficiency (PiZZ) is known to predispose to emphysema and chronic liver disease (CLD). The overall aim of the studies upon which this thesis is based was to investigate extra-pulmonary disease manifestations of AAT deficiency with special reference to hepatic and vasculitic disorders. READ MORE