Search for dissertations about: "alpha-2"

Showing result 1 - 5 of 29 swedish dissertations containing the word alpha-2.

  2. 1. Alpha-2 Adrenergic Receptors and Signal Transduction : Effector Output in Relation to G-Protein Coupling and Signalling Cross-Talk

    Author : Johnny Näsman; Peter Evans; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology and anatomy; Adrenergic; receptor; G-protein; adenylyl cyclase; cAMP; calcium; cross-talk; Fysiologi och anatomi; Physiology and pharmacology; Fysiologi och farmakologi; Physiology; fysiologi;

    Abstract : The alpha-2 adrenergic receptor (α2-AR) subfamily includes three different subtypes, α2A-, α2B- and α2C-AR, all believed to exert their function through heterotrimeric Gi/o-proteins. The present study was undertaken in order to investigate subtype differences in terms of cellular response and to explore other potential signalling pathways of α2-ARs. READ MORE

  4. 2. Psychosocial stress in relation to blood pressure and cardivascular disease - epidemiological and genetic aspects

    Author : Bertil Öhlin; Internmedicin - epidemiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; receptor; Cardiovascular system; Medicin människa och djur ; Medicine human and vertebrates ; adrenergic; alpha-2; beta-1; mortality; morbidity; prospective; studies; polymorphism; work; stress; blood pressure; hypertension;

    Abstract : Psychosocial stress has been linked to both hypertension and cardiovascular disease (CVD), and hypertension has been proposed to be one mediator of the increased CVD risk in subjects reporting stress. Genetic susceptibility for blood pressure elevation in relation to stress has been proposed, but so far there is little evidence. READ MORE

  5. 3. Pathogen-host interactions at the surface of Streptococcus pyogenes

    Author : Patrik Nyberg; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Infektioner; Infections; C3a; LL-37; antimicrobial peptide; GRAB; alpha-2-macroglobulin; proteolysis; SpeB; internalization; virulence; protein F1; Streptococcus pyogenes; fibronectin;

    Abstract : The bacterial surface can be thought of as the interface where pathogenic bacteria encounter the human host. Interactions between bacterial surface proteins and human proteins are important determinants of the eventual outcome of infection. READ MORE

  6. 4. In Search of Prognostic Factors in Grade 2 Gliomas

    Author : Dan Ribom; Tommy Bergenheim; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; low-grade glioma; positron emission tomography; platelet-derived growth factor receptor; mass spectrometry; alpha 2-HS glycoprotein; Neurovetenskap; Neurology; Neurologi; Neurology; Neurologi;

    Abstract : Grade 2 gliomas are malignant brain tumours affecting otherwise healthy adults. Although the long-term prognosis is poor, many patients are well and may have a high quality of life for several years. READ MORE

  7. 5. Experimental Injury to the Visual System : Molecular Studies of the Retina

    Author : Ulrika Lönngren; Finn Hallböök; Fredrik Ghosh; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; retina; injury; ischemia; gene expression; brimonidine; alpha-2-adrenergic agonist; neuroprotection; growth factors; apoptosis; Müller cells; Neuroscience; Neurovetenskap;

    Abstract : Retinal ganglion cells play a crucial role in the relay of visual signals from the eye to the brain. This cell type is affected and eventually lost in the eye disease glaucoma, resulting in progressive and irreversible loss of vision. READ MORE