Search for dissertations about: "alpha-Synuclein"
Showing result 1 - 5 of 49 swedish dissertations containing the word alpha-Synuclein.
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1. Alpha-Synuclein Oligomers : Cellular Mechanisms and Aspects of Antibody Treatment
Abstract : In Parkinson’s disease (PD) and dementia with Lewy bodies (DLB), aggregated α-synuclein deposit inside cells within the brain. Smaller soluble α-synuclein aggregates, oligomers, are present both intra- and extracellularly. READ MORE
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2. Characterization of Physiological and Pathological Alpha-Synuclein : Implications for Parkinson’s Disease and Related Disorders
Abstract : Aggregated alpha-synuclein is the main component of Lewy bodies and Lewy neurites, intraneuronal inclusions found in the brains of Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) patients (synucleinopathies). Alpha-synuclein is a presynaptic protein, which is most commonly an unfolded monomer in its physiological state. READ MORE
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3. GDNF and alpha-synuclein in nigrostriatal degeneration
Abstract : Parkinson’s disease is a common neurological disorder with a complex etiology. The disease is characterized by a progressive loss of dopaminergic cells in the substantia nigra, which leads to motor function and sometimes cognitive function disabilities. READ MORE
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4. Pathogenic effects of alpha-synuclein: modifications and toxicity
Abstract : Accumulation of intraneuronal inclusions, containing mainly a protein called alpha-synuclein (asyn), is thought to play a critical role in neurodegenerative disorders such as Parkinson's disease (PD). In these so called Lewy bodies, the majority of asyn is phosphorylated at serine 129 (pS129) suggesting that post-translational modifications may play a critical role in the process of aggregate formation. READ MORE
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5. Alpha-synuclein: pathology, peripheral expression, and environmental interactions
Abstract : .... READ MORE