Search for dissertations about: "alpha-helical peptides"

Found 5 swedish dissertations containing the words alpha-helical peptides.

  2. 1. Environmental influence on alpha-helical peptides

    Author : Ana Caballero Herrera; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MD alpha helix; C-peptide; membrane proteins; hydrogen bonds; packing; dynamics;

    Abstract : Most proteins at physiological conditions fold into a native functional three-dimensional conformation. The stability of the Native state is a balance between different interactions within the protein and with the solvent. READ MORE

  4. 2. Cellular targets of HAMLET, their role in tumor cell death and therapeutic potential

    Author : Aftab Nadeem; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer therapy; colon cancer; bladder cancer; cell death; HAMLET; alpha-lactalbumin; oleate; membrane lipids; nucleotide-binding protein; Ras GTPases; alpha-helical peptides;

    Abstract : Protein-lipid complexes have broad and specific effects against cancers of different origins. HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells) is a complex of partially unfolded α-lactalbumin and oleic acid that kills a wide range of tumor cells but leaves healthy differentiated cells unaffected. READ MORE

  5. 3. Biophysical studies of membrane interacting peptides derived from viral and Prion proteins

    Author : Kamila Oglęcka; Astrid Gräslund; Stephen White; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Prion peptides; Doppel peptide; Influenza fusion peptides; peptide-membrane interactions; translocation; linear dichroism; circular dichroism; Biophysics; Biofysik; Biophysics; biofysik;

    Abstract : This thesis focuses on peptides derived from the Prion, Doppel and Influenza haemagglutinin proteins in the context of bilayer interactions with model membranes and live cells. The studies involve spectroscopic techniques like fluorescence, fluorescence correlation spectroscopy (FCS), circular and linear dichroism (CD and LD), confocal fluorescence microscopy and NMR. READ MORE

  6. 4. Expression of cathelicidin antimicrobial peptides in man and rat

    Author : Stefan Termén; Karolinska Institutet; Karolinska Institutet; []
    Keywords : LL-37; rCRAMP; butyrate; colonic epithelium; central nervous system; transcription;

    Abstract : Endogenous antimicrobial peptides are effectors of innate immunity. They kill microorganisms by disrupting their cell membranes, but are also believed to have signaling functions in the immune system. They are present in epithelia, secretions and phagocytic cells. READ MORE

  7. 5. In-silico design of peptide-based transfection systems, in-vitro validation, and up-take pathways investigation

    Author : Moataz Dowaidar; Ülo Langel; IngMarie Nilsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptides; QSAR; PepFect; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Cell-penetrating peptide-based transfection systems (PBTS) are a promising group of drug delivery vectors. Cell-penetrating peptides (CPPs) are short cationic peptides that are able of transporting cell non-permeant cargos into different cell types. READ MORE