Search for dissertations about: "alprazolam"

Found 5 swedish dissertations containing the word alprazolam.

  2. 1. Clinical studies of panic disorder

    Author : Sven Andersch; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Panic disorder; alprazolam; imipramine; agoraphobia; social phobia; psychiatric comorbidity; MAO; long-term course; daily life functioning.;

    Abstract : Aims: To study efficacy and safety of alprazolam, imipramine, and placebo in treatment of panic disorder, to investigate comorbidity with social phobia, to determine platelet monoamine oxidase (MAO), and to follow the long-term course in a cohort of patients with panic disorder.Subjects and Methods: A double-blind comparison of alprazolam, imipramine, and placebo was performed in 123 Scandinavian outpatients with panic disorder according to DSM-III. READ MORE

  4. 2. The role of CYP3A4/5 in alprazolam metabolism

    Author : Annika Allqvist; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Cytochrome P450 3A (CYP3A) enzyme family is involved in the metabolism of about 50 % of all drugs in clinical use. Among CYP3A, CYP3A4 and CYP3A5 are the major enzymes in adults; however CYP3A5 is polymorphic and primarily expressed in black populations. READ MORE

  5. 3. Characteristics of cytochrome P450-catalysed drug metabolism with focus on a black Tanzanian population

    Author : Agneta Wennerholm; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Drug metabolism; cytochrome P450; polymorphism; pharmacogenetics; genotyping; phenotyping; CYP2D6; CYP3A; debrisoquine; amodiaquine; alprazolam;

    Abstract : The cytochrome P450 (CYP) enzymes display interindividual and interethnic variability that may alter the disposition of substances metabolised by these enzymes. Both genetic and environmental factors such as concomitant drug use and concurrent diseases influence the activities of these enzymes. READ MORE

  6. 4. Studies of drug disposition in hemodialysis patients : impact of genetics, inflammation and vitamin D

    Author : Hadi Molanaei; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Chronic kidney disease (CKD) patients are at a high risk for drug adverse effects due to accumulation of drugs, which normally are excreted via the kidneys. It is believed that drugs that are metabolized by the liver are safe to prescribe in normal doses to end-stage renal disease (ESRD) patients. READ MORE

  7. 5. Epidemiological studies of medication use and effectiveness in bipolar disorder

    Author : Louise Wingård; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : In the last decades, new treatments for bipolar disorder (BD) have emerged, prompting a decrease in the use of lithium – the former “gold standard” for relapse prevention, and increasing the possibilities for individualized treatment. The aims of this thesis were to: 1) explore the use of relapse prevention in the early phases of bipolar illness, 2) add to the current knowledge concerning the comparative effectiveness of various pharmacological maintenance treatments, including combination therapies, and 3) explore the use of benzodiazepines and non-benzodiazepine hypnotics (so called Z-drugs) in BD. READ MORE