Search for dissertations about: "altered hepatic foci"
Found 3 swedish dissertations containing the words altered hepatic foci.
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1. The attenuation of the P53 response to DNA damage in rodent liver preneoplastic enzyme-altered foci
Abstract : In connection with life-time bioassays in rodents, the liver is one of the organs most frequently affected. During the carcinogenic process, single preneoplastic hepatocytes develop into hepatocellular adenoma or carcinoma (HCC). READ MORE
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2. Liver tumour promoting effects by polychlorinated biphenyls
Abstract : PCBs cause a number of toxic effects and are present in a variety of biological samples including fish, meat and diary products. Cancer is a serious toxic effect by PCBs that has been observed in animal experiments but the knowledge about PCB induced carcinogenicity is still scarce. READ MORE
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3. Mechanistical studies on gap junctions and their role in tumour promotion : structure-activity relationships of polychlorinated biphelyls
Abstract : Chemically induced carcinogenesis is a multi-stage process that can be divided into at least three major stages, initiation, promotion and progression. The promotion stage involves clonal expansion of genetically altered cells (i.e. initiated cells). READ MORE