Search for dissertations about: "alternative pathway of complement"

Showing result 1 - 5 of 35 swedish dissertations containing the words alternative pathway of complement.

  2. 1. Initiation of alternative pathway of complement, and development of novel liposomal coatings

    Author : Anna Adler; Yuji Teramura; Penti Tengvall; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunology; complement system; C3; liposomes; polymer-lipids; Immunologi; Immunology;

    Abstract : The complement system is a central part of the innate immune system, and is an essential part in recognizing and clearing non/altered-self surfaces in the body. This thesis comprises of projects in which the initiation of the alternative pathway (AP) of complement in the fluid phase as well on various artificial and lipid surfaces has been studied. READ MORE

  4. 2. Complement in Disease - Extracellular Proteins as Complement Regulators

    Author : Kaisa Happonen; Malmö Proteinkemi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatoid arthritis; joint disease; Complement; proteoglycan; cancer;

    Abstract : Complement activation occurs during inflammatory joint diseases such as rheumatoid arthritis (RA) and is thought to contribute to the chronic inflammation observed within the joints. Previous studies have shown that certain cartilage components of the small leucine-rich repeat protein (SLRP)-family regulate complement activity, thereby possibly contributing to disease progression. READ MORE

  5. 3. Studies of EHEC and the complement system in renal diseases

    Author : Zivile Békassy; Lund Pediatrik; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; EHEC; hemolytic uremic syndrome; thrombotic microangiopathy; atypical hemolytic uremic syndrome; alternative pathway of complement; dense deposit disease; eculizumab;

    Abstract : This thesis addressed the diagnosis, pathogenesis and clinical course of specific renal diseases hemolytic uremic syndrome (HUS) and dense deposit disease (DDD). HUS may be associated with infection caused by Enterohemorrhagic Escherichia coli (EHEC) or with complement dysfunction due to complement mutations or auto-antibodies (atypical HUS, aHUS). READ MORE

  6. 4. Complement aberrations and autoantibodies to complement proteins in relation to disease mechanisms

    Author : Lillemor Melander Skattum; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; C3 nephritic factors; GM allotypes; C1q autoantibodies; serum bactericidal activity; Neisseria meningitidis; idiopathic sudden hearing loss; complement; Acute poststreptococcal glomerulonephritis;

    Abstract : The complement system, a part of the innate immune system with several links to the adaptive immune system, plays an important role in the pathogenesis of many diseases. The purpose of this thesis was to document and clarify some of these mechanisms. The thesis is based on four papers (I-IV). READ MORE

  7. 5. The role of the complement system in arthritis and stroke

    Author : Max Albert Hietala; Göteborgs universitet; []
    Keywords : complement; C3; factor B; transgenic knockout; arthritis; focal cerebral ischemia;

    Abstract : Complement is part of the innate immune system and functions primarily as a first line of defense against invading microorganisms. It is a complex cascade, which can be activated via three pathways: the classical, alternative and mannan-binding lectin pathway. READ MORE